Extended Data Table 3. Association among clinical characteristics and CH mutational characteristics.

Myeloid PD, genes mutated in myeloid neoplasms; non-myeloid, genes not linked to myeloid neoplasms; myeloid PD, variants known to be myeloid drivers or putative somatic driver mutations in myeloid neoplasms; myeloid non-PD, mutations within genes linked to myeloid neoplasms but that are not putative drivers; non-myeloid PD, mutations that are putative somatic driver mutations of cancer in genes not linked to myeloid neoplasms; non-myeloid non-PD, mutations within genes not linked to myeloid neoplasms that are not putative drivers of cancer. Associations were evaluated using multivariable logistic regression models to generate heterogeneity p-values. Sensitivity analyses restricted to individuals with only one mutation yielded similar results. Age expressed in decile.

Variable (reference)		OR	95% CI	p
Age	-	1	1–1.1	0.0011
Ethnicity (white)	Asian	1	0.94–1.2	0.42
	Black	0.9	0.82–1	0.053
	Other	0.93	0.83–1	0.24
	Unknown	0.92	0.8–1.1	0.22
Smoke (non-smoker)	Smoker	1.1	1.1–1.2	0.000023
Therapy (untreated)	Treated	1	0.96–1.1	0.8
PD status (non-PD non-myeloid)	Myeloid PD	1.3	1.3–1.4	< 1 × 10−6
	Non-myeloid PD	1.3	1.2–1.5	0.000052
	Non-PD myeloid	0.99	0.92–1.1	0.8
Number of mutations (1)	≥ 2	1.1	1.1–1.2	0.0000038