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. 2021 Feb 18;48(1):40–51. doi: 10.1016/j.jgg.2021.01.004

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Distribution of P323 L/F (nsp12, RdRp) in Nevada. A: Cumulative frequency of P323 L/F (nsp12, RdRp) in 173 patient specimens from Nevada during March 6 to June 5. The amino acid at position 323 is indicated by teal for proline (P), yellow for leucine (L), and blue for phenylalanine (F). Pie charts depict the cumulative proportion up to the indicated time point (March 15, April 1, May 1, June 5). The total number of specimens included at each time point is specified below each pie chart. Dates of emergency orders and regulations meant to slow the spread of SARS-CoV-2 in Nevada are indicated on the time scale of the frequency graph. B: Circular dendrogram representing the distribution of amino acid change at residue 323 of nsp12 from a global subsampling of sequences deposited in Nextstrain.org from March 6 to June 5, the larger dots indicate specimens from Nevada. C: Pie chart indicating the ratio of P/L/F in Northern NV and Southern NV specimens from this study. D: Proportion of P323 L/F from a subsampling of sequences deposited in Nextstrain.org for the United States and E: global regions from March 6 to June 5. The size of the pie chart corresponds to the relative specimen number for each region.