Table 1.

Model variables

Variable	Description
BC	BMAL1-CLOCK; protein dimer that drives the transcription of
	core clock genes
Pi	PERIOD protein (PER) with i phosphorylations in the cytosol
C	CRYPTOCHROME protein (CRY) in the cytosol
PC	PER-CRY protein dimer in the cytosol
PCN	nuclear PER-CRY protein dimer; inhibits BMAL1-CLOCK
PN	nuclear PER
CN	nuclear CRY; inhibits transcription driven by BMAL1-CLOCK
ROR	retinoic acid receptor-related orphan receptor (ROR)
REV	orphan nuclear receptor REV-ERB
S	Bmal1; circadian clock gene
TH	Tyrosine hydroxylase (TH); rate-limiting enzyme in dopamine
	synthesis
MAO	Monoamine oxidase (MAO); catalyzes dopamine degradation
DRD3	Dopamine receptor D3 (DRD3)