Table 1.

Detailed participant schedule

		Treatment phase
Activity	Screening	Week −2a	Week 0	Week 2	Week 4	Week 8	Week 12	Week 16
Clinic visit		X	X	X		X		X
Review eligibility	X	X	X
Informed consent	X	X	X
Salivary DNA sample	X
Demography	X	X	X
Medical history		X	X					X
Medical examination		Xc	Xc					Xc
Weight, height, BMI		X	X			X		X
Medication review		X	X	X		X		X
Clinic blood pressure		X	X	X		X		X
Blood sampling		X	X	X		X		X
ECG			Xc					Xc
Urine sampling			Xb			X		Xb
ABPM			X			X		X
HBPM	X				X		X
Compliance check				X		X		X
Adverse events reporting				X		X		X
Dispense study medication			X			X

Abbreviations: ABPM, ambulatory blood pressure monitoring; BMI, body mass index; ECG, electrocardiogram; HBPM, home blood pressure monitoring.

^aIf on diuretics prior to study.

^bIncluding pregnancy testing for women of childbearing potential.

^cNot required for all participants, at discretion of the investigator.