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Aldosterone and activation of adaptive immune cells. Aldosterone induces activation of dendritic cells and increased polarization of CD4+ naive T cells into Th17, Th1, and decreased Treg cells. Aldosterone also increases recruitment of B lymphocytes and activation of CD8+ T cells. Abbreviations: IFN, interferon; IL, interleukin; TGF, transforming growth factor; Th, T helper cells; TNF, tumor necrosis factor; Treg, T regulatory cells.
