Evidence‐based recommendation (2.16)
Due to concerns about patient's health and the impact of systemic antibiotic use to public health, its routine use as adjunct to subgingival debridement in patients with periodontitis is not recommended. The adjunctive use of specific systemic antibiotics may be considered for specific patient categories (e.g. generalized periodontitis Stage III in young adults).
Supporting literature Teughels et al. (2020)
Quality of evidence RCTs (n = 28) with a double‐blind, placebo‐controlled, parallel design. Risk of bias was low for 20 of the studies, while seven studies had a high risk. PPD reduction at 6 months; MET + AMOX: n = 8, 867 patients. PPD reduction at 12 months; MET + AMOX: n = 7, 764 patients, MET: n = 2, 259 patients.
Grade of recommendation Grade A—↓↓ Grade of recommendation Grade 0—↔
Strength of consensus Consensus (0% of the group abstained due to potential CoI) Strength of consensus Consensus (0% of the group abstained due to potential CoI)