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Model depicting mt‐mRNA fate in normal and mt‐LSU‐depleted cells. Cartoon showing processed and matured mt‐mRNAs within RNA granules (A). This model proposes that LRPPRC/SLIRP stabilizes mature mt‐mRNAs (B) and delivers them to either the mt‐SSU or the monosome (C). In this scenario, the mt‐mRNAs are translated. If mt‐LSU levels are low, as with mtVapC20 expression (D), mt‐mRNAs are still transferred to mt‐SSU but are degraded due to the lack of protection by the monosome.
