TABLE 3.
Selected genes identified as potential upstream regulators of arrested embryo growth. Genes associated with stem cells, BMP signaling, and EMT were particularly enriched
| (a) Stem cell associated genes | ||
|---|---|---|
| Upstream regulator | Molecule type | P‐value of overlap |
| SOX2 | Transcription regulator | 3,72E‐16 |
| POU5F1/OCT4 | Transcription regulator | 5,29E‐16 |
| E2F4 | Transcription regulator | 2,66E‐12 |
| KLF4 | Transcription regulator | 2,61E‐11 |
| NANOG | Transcription regulator | 2,81E‐07 |
| EZH2 | Transcription regulator | 2,69E‐08 |
| GLI1 | Transcription regulator | 1,68E‐05 |
| NOTCH1 | Transcription regulator | 2,31E‐03 |
| KLF2 | Transcription regulator | 3,00E‐03 |
| SALL4 | Transcription regulator | 1,67E‐02 |
| HEY1 | Transcription regulator | 1,97E‐02 |
| KLF6 | Transcription regulator | 2,66E‐02 |
| HEY2 | Transcription regulator | 3,57E‐02 |
| BMI1 | Transcription regulator | 2,84E‐04 |
| (b) BMP signaling associated genes | ||
|---|---|---|
| Upstream regulator | Molecule type | P‐value of overlap |
| BMP4 | Growth factor | 5,74E‐11 |
| BMP2 | Growth factor | 2,69E‐03 |
| BMP10 | Growth factor | 5,06E‐03 |
| BMP6 | Growth factor | 1,17E‐02 |
| SMAD2 | Transcription regulator | 5,66E‐09 |
| SMAD7 | Transcription regulator | 8,82E‐06 |
| SMAD4 | Transcription regulator | 5,43E‐05 |
| SMAD3 | Transcription regulator | 1,38E‐03 |
| (c) EMT associated genes | ||
|---|---|---|
| Upstream regulator | Molecule type | P‐value of overlap |
| SNAI1 | Transcription regulator | 8,22E‐04 |
| ZEB2 | Transcription regulator | 1,44E‐03 |
| TWIST1 | Transcription regulator | 3,00E‐03 |
| ZEB1 | Transcription regulator | 1,10E‐02 |
| LEF1 | Transcription regulator | 2,03E‐02 |
| NODAL | Growth factor | 2,13E‐02 |
Abbreviation: EMT, epithelial‐to‐mesenchymal transition.