TABLE 4.
Complete list of genes identified as potential upstream regulators of arrested embryo growth
| Upstream of arrest in embryo growth | |||
|---|---|---|---|
| Upstream regulator | Molecule type | P‐value of overlap | Target molecules in dataset |
| MYC | Transcription regulator | 1.40E‐22 | ABCA1,ACACA,ACVR1,ACVR2A,AMD1,ATF2,CASP8,CDK2,CDK4,CDK6,CDKN2A,CDX2,COMMD3‐BMI1,CUL1,DDX11,DLX3,DNMT1,EOMES,EZH2,F2,FOXA2,G6PD,GATA4,GCLC,HAND1,HIF1A,KAT2A,KRAS,LIMS1,Macf1,MAX,MCL1,METAP2,MGAT1,MYCN,OTX2,PARP1,PNO1,RAB10,RAD51,RB1,SLC25A19,SMAD4,SUMO2,TDG,TDGF1,TLN1,TP53,TXN,TXNRD1,WLS |
| SOX2 | Transcription regulator | 3.72E‐16 | ACVR1,ACVR2A,CDKN2A,CDX2,COMMD3‐BMI1,DLX3,DNMT1,EOMES,FGF4,FLT1,FOXA2,GATA4,GSC,HAND1,ISL1,Macf1,MAX,MYCN,NOTCH1,OTX2,SMAD4,SNAI1,TDGF1,TXNRD1,WLS |
| POU5F1 | Transcription regulator | 5.29E‐16 | ACVR1,ACVR2A,CDX2,DLX3,DNMT1,EOMES,FGF4,FOXA2,GATA4,GSC,HAND1,HIF1A,ISL1,Macf1,MAX,MCL1,MYCN,PARP1,SMAD4,SNAI1,TDGF1,TP53,TXNRD1,WLS,ZEB2 |
| RB1 | Transcription regulator | 1.67E‐14 | ATF2,BECN1,CASP8,CDK2,CDKN2A,CDX2,CHAF1A,DDX11,DNMT1,EOMES,EZH2,FLT1,MCM10,MTOR,MYL1,PARP1,RAD51,RB1,RBL2,SDHD,SMARCA5,TOPBP1,TP53,TUBG1,ZEB2 |
| E2F1 | Transcription regulator | 5.03E‐13 | BECN1,CASP8,CDK2,CDK4,CDKN2A,DDX11,DNMT1,EZH2,FLT1,GINS1,HSP90B1,KRAS,MCL1,MCM10,MYCN,PIK3C3,RAD51,RB1,RBBP8,REV3L,SMARCA5,TOPBP1,TP53,TXNRD1,UHRF1,XRCC1 |
| E2F4 | Transcription regulator | 2.66E‐12 | BECN1,CDK2,DDX11,GINS1,HSP90B1,MCL1,MCM10,MYCN,NASP,RAD51,RB1,RBBP8,RBL2,SHH,SMARCA5,TOPBP1,TP53,UHRF1 |
| TGFB1 | Growth factor | 4.38E‐12 | ABCA1,ACVR1,ACVRL1,AMD1,APLNR,BECN1,CASP8,CDC7,CDH5,CDK2,CDK4,CDKN2A,CTCF,DNMT1,EHMT2,EOMES,F2,F2RL1,FLT1,FOXA2,GCLC,GNA13,HIF1A,KRAS,LDB1,LIMS1,MAPK7,MYCN,NOC3L,NOTCH1,PCGF2,PIK3C3,PNO1,PSMC3,RAC1,RAD51,RASA1,RB1,RBL2,SMAD2,SMAD4,SNAI1,SOX4,THBD,TP53,TXNRD1,VCL,ZEB2 |
| KLF4 | Transcription regulator | 2.61E‐11 | ACVR1,ACVR2A,CDX2,DLX3,EOMES,FLT1,GATA4,HAND1,Macf1,NF1,NOTCH1,OTX2,SMAD4,TDGF1,THBD,TP53,TXNRD1,WLS |
| BMP4 | Growth factor | 5.74E‐11 | ACVR2A,ACVR2B,CDH5,CDK2,CDKN2A,CDX2,DLX3,MYCN,PTCH1,SHH,SNAI1,SPINT1,TAL1,TBX5,TDGF1,TP53 |
| TP63 | Transcription regulator | 3.81E‐10 | ATF2,BECN1,CDK6,CDKN2A,DICER1,DNMT1,FOXA2,G6PD,HIRA,IHH,MCM10,NOTCH1,RAD51,RAD9A,RBBP8,SMAD2,SMAD4,SNAI1,TP53,ZEB2 |
| EGF | Growth factor | 1.75E‐09 | ARC,CDK2,CDK4,CDKN2A,CDX2,CTCF,FLT1,FOXA2,HIF1A,HIRA,KRAS,MCL1,MYCN,NOTCH1,Nrg1,RAC1,SNAI1,SOX4,TBP,TP53,TRPM7,VCL |
| HDAC1 | Transcription regulator | 2.55E‐09 | ARC,CDK2,CDKN2A,COMMD3‐BMI1,EHMT2,FLT1,MCM10,NASP,PCYT1A,SLC8A1,SNAI1,TAL1,TBX5,TP53,UHRF1,USP7 |
| FOXM1 | Transcription regulator | 3.15E‐09 | ATF2,CDK2,CDKN2A,COMMD3‐BMI1,FLT1,MYCN,PLK4,PTCH1,SNAI1,TP53,XRCC1,ZEB2 |
| RNF2 | Transcription regulator | 3.34E‐09 | CDKN2A,CDX2,COMMD3‐BMI1,EOMES,FOXA2,GATA4,HAND1,PCGF2,TP53 |
| GMNN | Transcription regulator | 3.98E‐09 | ACVR1,ACVR2A,CDX2,EOMES,HAND1,Macf1,SMAD4,TP53,TXNRD1,WLS |
| TP53 | Transcription regulator | 5.56E‐09 | CASP8,CDC7,CDK2,CDK4,CDKN2A,DICER1,DLD,DNMT1,EZH2,FOXA2,FXN,G6PD,GATA4,GNA13,HIF1A,HTT,LIAS,MCL1,MGAT1,NOTCH1,PARP2,PCGF2,PIK3C3,PNO1,PTCH1,PTPN11,RAD50,RAD51,RAF1,RB1,RBL2,SDHD,SNAI1,TBP,TBX5,TDG,THBD,TLN1,TP53,TSG101,UHRF1,VCL,ZEB2 |
| SMAD2 | Transcription regulator | 5.66E‐09 | BECN1,CDH5,CDKN2A,CDX2,FLT1,GSC,RAC1,SMAD2,SMAD4,SNAI1 |
| SOX1 | Transcription regulator | 1.98E‐08 | ACVR1,ACVR2A,CDX2,EOMES,HAND1,Macf1,SMAD4,TXNRD1,WLS |
| SP110 | Transcription regulator | 2.23E‐08 | ATF2,DICER1,FLII,GNA13,MCL1,MYCN,PLCG1,RAC1,RARRES2,SMAD2,SOX4 |
| EZH2 | Transcription regulator | 2.69E‐08 | CDK4,CDK6,CDKN2A,CDX2,CUL1,DNMT1,EOMES,EP300,EZH2,FGF4,FLT1,GATA4,KRAS,RNASEH1,SHH,SNAI1,TP53 |
| RBL1 | Transcription regulator | 2.84E‐08 | CDK2,CDKN2A,MCM10,MTOR,MYCN,NOTCH1,RB1,RBL2,TP53 |
| PCGF2 | Transcription regulator | 2.97E‐08 | CDK4,CDK6,CDKN2A,CDX2,GATA4,NOTCH1,TP53 |
| AGT | Growth factor | 3.31E‐08 | BECN1,CASP8,CDK4,CDKN2A,FLT1,HIF1A,KRAS,MAPK7,PARP1,RAC1,RIPK3,SLC8A1,SOX4,TBX20,TBX5,THBD,TP53,TRPM7,ZEB2 |
| SOX3 | Transcription regulator | 3.58E‐08 | ACVR1,ACVR2A,CDX2,EOMES,HAND1,Macf1,SMAD4,TXNRD1,WLS |
| E2F3 | Transcription regulator | 7.82E‐08 | BECN1,CDK2,CDKN2A,DAG1,EZH2,KRAS,MCM10,MYCN,RAD51,RB1,THBD,TOPBP1 |
| HGF | Growth factor | 1.55E‐07 | ATF2,CASP8,CDK2,CDK4,CDKN2A,DDX11,FLT1,FOXA2,GNA13,MCL1,Nrg1,PLK4,RAC1,RAD50,RARRES2,SNAI1,THBD,TOPBP1,TP53 |
| NANOG | Transcription regulator | 2.81E‐07 | CDK6,EOMES,FOXA2,GATA4,GSC,ISL1,MAX,MYCN,SRRT,TP53 |
| E2F2 | Transcription regulator | 2.83E‐07 | BECN1,CDKN2A,EZH2,MCM10,MYCN,RAD51,TOPBP1,TP53 |
| PTTG1 | Transcription regulator | 3.89E‐07 | HIF1A,PARP2,RAD50,RAD9B,REV3L,SNAI1,TDG,TP53 |
| EIF4E | Translation regulator | 5.63E‐07 | CDK2,CDK4,CDKN2A,EP300,HIF1A,MCL1,NRAS,RB1,SNAI1,TP53 |
| VEGFA | Growth factor | 5.73E‐07 | CDH5,CDKN2A,EOMES,FLT1,HIF1A,LDB1,MCL1,MYCN,NOTCH1,PARP1,SDHD,TAL1,THBD,TP53 |
| SRF | Transcription regulator | 5.80E‐07 | AMD1,ARC,CDK4,FLT1,GATA4,MCL1,MYL1,RAF1,SHH,SLC8A1,SNX2,TAL1,TBP,TLN1,VCL |
| HNF4A | Transcription regulator | 7.49E‐07 | ACVR1,APH1A,ATF2,ATF7,CDK2,DAG1,DLX3,FOXA2,G6PD,HIF1A,HNF1B,HSP90B1,KAT7,LDB1,LIMS1,MAPK7,METAP2,NOC3L,NRAS,OTX2,PAGR1,PCGF2,PCYT1A,PELO,PIK3C3,PNO1,PSMC4,PTPN11,RAB10,RAD50,RAD51,RASA1,RBL2,SHH,SLC25A19,SLC33A1,SMAD4,SMARCA5,TLN1,TSG101,TXN,TXNRD1 |
| SP1 | Transcription regulator | 9.58E‐07 | ABCA1,ACVRL1,CDK2,CDK4,CDK6,CDKN2A,DLX3,FLT1,HIF1A,MCL1,MYCN,NF1,PARP1,PCYT1A,RB1,THBD,TP53,TXNRD1,ZEB2 |
| FOXO3 | Transcription regulator | 1.55E‐06 | ACVR1,BECN1,CASP8,CDH5,CDK4,GCLC,HIF1A,MAX,RASA1,RBL2,SMAD4,SNAI1,TAL1,TP53 |
| INHBA | Growth factor | 1.63E‐06 | ACVR1,ACVR1B,ACVR2A,ACVR2B,CDK4,FOXA2,KRAS,MCL1,SMAD2,SOX4,TAL1 |
| NKX2‐5 | Transcription regulator | 1.75E‐06 | ACACA,BMP10,GATA4,HAND1,MYCN,TBX5 |
| CCND1 | Transcription regulator | 2.29E‐06 | CDK2,CDK4,CDK6,CDKN2A,DNMT1,GATA4,MCM10,NOTCH1,PCYT1A,RAD51,RB1,SOX4,TP53,UHRF1 |
| TBX20 | Transcription regulator | 2.89E‐06 | BMP10,MYCN,TBX5 |
| HNRNPK | Transcription regulator | 3.07E‐06 | ATF2,FGF4,G6PD,HUS1,RASA1,RB1 |
| CDKN2A | Transcription regulator | 3.20E‐06 | AMD1,CDK2,CDKN2A,CHAF1A,CUL1,EZH2,GNA13,KRAS,MCL1,MYCN,RB1,TP53,TSG101 |
| PML | Transcription regulator | 3.48E‐06 | ACACA,CDK2,CDKN2A,SNAI1,SUMO2,TOPBP1,TP53,TXN,TXNRD1 |
| ETS1 | Transcription regulator | 4.81E‐06 | CDH5,CDK11A,CDK2,CDK6,CDKN2A,FLT1,MCL1,PARP1,SNAI1,TP53,ZEB2 |
| CTNNB1 | Transcription regulator | 6.93E‐06 | ACVR2A,CDKN2A,COMMD3‐BMI1,EOMES,FOXA2,GNA12,IHH,ISL1,MCL1,MYCN,NOTCH1,PTCH1,SHH,SNAI1,SOX11,SOX4,TBX20,TBX5,TDGF1,TP53,ZEB2 |
| NCOA1 | Transcription regulator | 7.48E‐06 | ABCA1,CASP8,EOMES,HIF1A,HIRA,LIAS,PDCD2,POU2F1,RB1 |
| CITED2 | Transcription regulator | 8.06E‐06 | CDKN2A,CDX2,COMMD3‐BMI1,HIF1A,PCGF2 |
| SMAD7 | Transcription regulator | 8.82E‐06 | ACVR1,ACVR1B,ACVR2A,ACVR2B,BMPR2,FOXA2,GATA4,RAC1,TXN |
| MED1 | Transcription regulator | 1.41E‐05 | ACACA,ARID1A,CDK2,CDK4,CHAF1A,MCL1,MYCN,NF1,TP53 |
| TEAD4 | Transcription regulator | 1.50E‐05 | CDX2,EOMES,FLT1,GATAD2A,HIF1A |
| GLI1 | Transcription regulator | 1.68E‐05 | ARC,CDK2,COMMD3‐BMI1,FOXA2,GATA4,MYCN,PTCH1,SNAI1,TP53,USP7 |
| FGF2 | Growth factor | 1.99E‐05 | ARC,CDX2,FLT1,HIF1A,HIRA,KRAS,MYCN,NF1,NOTCH1,RAF1,RB1,SHH,SNAI1,TP53 |
| STAT3 | Transcription regulator | 2.24E‐05 | BECN1,CDH5,CDKN2A,COPS5,DNMT1,EOMES,FLT1,HIF1A,IHH,MCL1,NOTCH1,POU2F1,SHH,SNAI1,THBD,TP53,USP7 |
| CCNH | Transcription regulator | 2.26E‐05 | CDX2,COMMD3‐BMI1,GATA4,HAND1 |
| EED | Transcription regulator | 2.92E‐05 | CDKN2A,CDX2,GATA4,SHH,TBX5 |
| SIRT1 | Transcription regulator | 3.16E‐05 | ABCA1,ATF7,CDKN2A,EP300,GATA4,HIF1A,MGAT1,NF1,PARP1,RAC1,TAL1,THBD,TP53 |
| HDAC2 | Transcription regulator | 3.22E‐05 | CDK2,CDKN2A,COMMD3‐BMI1,MCM10,MYCN,NASP,SLC8A1,TP53 |
| ID1 | Transcription regulator | 4.10E‐05 | CDKN2A,FOXA2,MESP1,NOTCH1,PCGF2,SNAI1 |
| EIF4G1 | Translation regulator | 4.17E‐05 | HIF1A,RAD50,RAD51,TP53 |
| NRG1 | Growth factor | 4.36E‐05 | ABCA1,CDX2,DAG1,GATA4,HIF1A,MCL1,NOTCH1,SNAI1,SOX4,VCL |
| FOXO1 | Transcription regulator | 4.46E‐05 | ACACA,CASP8,CDH5,CDKN2A,EOMES,FOXA2,HIF1A,HUS1,MYCN,PIK3C3,RBL2,SLC25A19,SMAD4,TP53 |
| YAP1 | Transcription regulator | 4.50E‐05 | CASP8,CDK6,CDX2,DICER1,RAD51,SMAD2,UHRF1 |
| FGF7 | Growth factor | 4.82E‐05 | CDK2,CDK4,CDKN2A,Nrg1,SHH,TP53 |
| SMAD4 | Transcription regulator | 5.43E‐05 | CDH5,CDKN2A,MAPK7,MTOR,MYCN,RAC1,SHH,SMAD2,SMAD4,SNAI1 |
| MDM2 | Transcription regulator | 5.63E‐05 | CDK4,CDKN2A,HIF1A,MYCN,TP53,TSG101 |
| SHOX | Transcription regulator | 5.87E‐05 | RB1,RBL2,TP53 |
| PSMD10 | Transcription regulator | 5.98E‐05 | CDK2,CDK4,HIF1A,TP53 |
| CEBPA | Transcription regulator | 6.27E‐05 | ACACA,APLNR,CDK4,COPS5,DLX3,FLT1,FOXA2,HNF1B,KDM1A,MYCN,OTX2,RARRES2,THBD,VCL |
| SREBF2 | Transcription regulator | 6.54E‐05 | ABCA1,ACACA,G6PD,PCYT1A,PTCH1,RARRES2 |
| GATA6 | Transcription regulator | 6.82E‐05 | BMPR2,CDX2,DLD,DLX3,FOXA2,GATA4,HNF1B,OTX2,SHH |
| HAND1 | Transcription regulator | 7.07E‐05 | ACACA,FLT1,HAND1,NOTCH1 |
| CCNE1 | Transcription regulator | 8.29E‐05 | CDK2,HIF1A,PCYT1A,TP53 |
| GATA4 | Transcription regulator | 9.31E‐05 | ACACA,BECN1,CDX2,DLX3,GATA4,MYL1,OTX2,SLC8A1,TAL1 |
| IRF4 | Transcription regulator | 9.38E‐05 | CDK2,CDK6,CDKN2A,EOMES,FLT1,RAC1,RAD51,XRCC1 |
| TLX1 | Transcription regulator | 1.12E‐04 | MCL1,RAD51,RAF1,TAL1 |
| TEAD2 | Transcription regulator | 1.14E‐04 | RAD51,TP53,UHRF1 |
| RUNX2 | Transcription regulator | 1.18E‐04 | CSNK2B,HIF1A,IHH,ISL1,SHH,SNAI1,TLN1 |
| ARNT | Transcription regulator | 1.24E‐04 | CDK4,FLT1,G6PD,HIF1A,Macf1,SHH,TP53 |
| PAX6 | Transcription regulator | 1.35E‐04 | CDK2,CDK6,EOMES,F2,ISL1,OTX2,SMAD2,SMAD4,WLS |
| PITX2 | Transcription regulator | 1.37E‐04 | ATF2,EOMES,FOXA2,ISL1,SNAI1,TBX5,ZEB2 |
| ELK1 | Transcription regulator | 1.51E‐04 | BMPR2,CDKN2A,GRK2,MCL1,SNAI1 |
| ZIC3 | Transcription regulator | 1.95E‐04 | FOXA2,GATA4,TBX5 |
| BRCA1 | Transcription regulator | 2.06E‐04 | EP300,NOTCH1,POU2F1,RAD51,RB1,RBL2,TBP,TP53 |
| YEATS4 | Transcription regulator | 2.43E‐04 | CDKN2A,TP53 |
| TERF1 | Transcription regulator | 2.43E‐04 | CDKN2A,TP53 |
| ELF4 | Transcription regulator | 2.43E‐04 | CDKN2A,DLX3,PIK3C3,TP53 |
| MYCN | Transcription regulator | 2.66E‐04 | ABCA1,CDH5,COMMD3‐BMI1,EZH2,FOXA2,GATA4,MYCN,SLC25A19,TP53,ZEB2 |
| TFDP1 | Transcription regulator | 2.73E‐04 | CASP8,CDKN2A,MYCN,TP53 |
| BMI1 | Transcription regulator | 2.84E‐04 | CASP8,CDKN2A,CUL1,DNMT1,TP53 |
| EGR1 | Transcription regulator | 3.11E‐04 | ARC,CASP8,FLT1,HIF1A,RB1,SHH,SNAI1,TP53 |
| GLI2 | Transcription regulator | 3.50E‐04 | DLX3,FOXA2,GATA4,MYCN,PTCH1,SNAI1 |
| MESP1 | Transcription regulator | 3.74E‐04 | GATA4,SNAI1,ZEB2 |
| MAFG | Transcription regulator | 3.74E‐04 | GCLC,TP53,TXNRD1 |
| GLI3 | Transcription regulator | 3.77E‐04 | COMMD3‐BMI1,FOXA2,MYCN,PTCH1,SHH |
| TGFB2 | Growth factor | 4.08E‐04 | ABCA1,CDH5,CDKN2A,NOTCH1,OSR1,SMAD2 |
| IGF1 | Growth factor | 4.31E‐04 | ABCA1,ACACA,CDK2,CDK4,CDKN2A,HIF1A,IHH,KAT2A,MCL1,MYCN,PARP1,TP53,UBTF |
| MESP2 | Transcription regulator | 4.51E‐04 | GATA4,SNAI1,ZEB2 |
| LYL1 | Transcription regulator | 5.37E‐04 | CDH5,RAPGEF2,TAL1 |
| JARID2 | Transcription regulator | 5.37E‐04 | CDX2,HAND1,NOTCH1 |
| RELA | Transcription regulator | 5.71E‐04 | BECN1,CASP8,CDKN2A,CTCF,EOMES,HIF1A,HSP90B1,NOTCH1,SHH,SMAD4,SNAI1,TP53 |
| KAT2B | Transcription regulator | 6.63E‐04 | COMMD3‐BMI1,PTCH1,RB1,TP53 |
| HR | Transcription regulator | 7.23E‐04 | AMD1,DLX3,PLCG1,UBR2 |
| HOXA5 | Transcription regulator | 7.41E‐04 | IHH,SHH,TP53 |
| HTT | Transcription regulator | 7.60E‐04 | ABCA1,AMD1,CDK2,DLX3,EP300,GCLC,GRK2,GSC,HIF1A,HTT,KAT2A,MTOR,MYL1,OTX2,RAB10,TP53 |
| POU2F1 | Transcription regulator | 8.22E‐04 | ATF2,CDX2,FGF4,HNF1B,ISL1,POU2F1 |
| SNAI1 | Transcription regulator | 8.22E‐04 | CDH5,CDK2,CDK4,SNAI1,THBD,ZEB2 |
| MAFK | Transcription regulator | 8.59E‐04 | GCLC,TXN,TXNRD1 |
| ID2 | Transcription regulator | 9.88E‐04 | CDK4,CDKN2A,EOMES,HIF1A,MAPK7,NOTCH1,SOX4 |
| TP73 | Transcription regulator | 1.02E‐03 | CDK2,FLT1,G6PD,MYCN,NOTCH1,RB1,SNAI1,SPINT1,TBX5,TP53,XRCC1 |
| TAL1 | Transcription regulator | 1.05E‐03 | AFDN,CDH5,CDK6,CDKN2A,GINS1,NOTCH1,PLCG1,SOX4 |
| FGF4 | Growth factor | 1.13E‐03 | DNMT1,FOXA2,SHH |
| ZBTB7A | Transcription regulator | 1.13E‐03 | CDK2,CDKN2A,NRAS |
| STAT5A | Transcription regulator | 1.13E‐03 | CASP8,CDC7,CDK4,CDK6,EOMES,EZH2,MCL1,SLC34A2,TP53 |
| Rhox4b (includes others) | Transcription regulator | 1.19E‐03 | CDH5,TAL1 |
| KLF17 | Transcription regulator | 1.19E‐03 | RB1,TP53 |
| ID3 | Transcription regulator | 1.25E‐03 | CDKN2A,EOMES,HIF1A,MAPK7,NOTCH1,SOX4,TP53 |
| SMAD3 | Transcription regulator | 1.38E‐03 | CDH5,CDK4,CDKN2A,MAX,RAC1,SNAI1,TDGF1,ZEB2 |
| ZEB2 | Transcription regulator | 1.44E‐03 | CDKN2A,EHMT2,PLCG1,SNAI1 |
| MITF | Transcription regulator | 1.46E‐03 | CDK2,CDKN2A,CHAF1A,HIF1A,OTX2,SNAI1,TDG,TP53 |
| GATA1 | Transcription regulator | 1.54E‐03 | CDK2,CDK4,CDK6,CDKN2A,COPS5,DICER1,MYCN,TAL1 |
| SMARCA4 | Transcription regulator | 1.56E‐03 | ABCA1,CDK2,CDKN2A,COMMD3‐BMI1,FOXA2,GCLC,LDB1,MYL1,PTCH1,RAD50,SHH,SS18,TP53,TXNRD1 |
| DLX5 | Transcription regulator | 1.62E‐03 | GSC,HAND1,SHH |
| FGF9 | Growth factor | 1.62E‐03 | GCLC,PTCH1,SHH |
| FOXO4 | Transcription regulator | 1.64E‐03 | ACACA,CASP8,CDH5,HIF1A,RBL2 |
| FOXC2 | Transcription regulator | 1.65E‐03 | MESP1,NOTCH1,SNAI1,TP53 |
| RAX | Transcription regulator | 1.66E‐03 | NOTCH1,OTX2 |
| E4F1 | Transcription regulator | 1.66E‐03 | DLD,SLC25A19 |
| DMTF1 | Transcription regulator | 1.66E‐03 | CDKN2A,TP53 |
| HDAC5 | Transcription regulator | 1.76E‐03 | ARC,CASP8,MAPK7,SLC8A1 |
| AMH | Growth factor | 1.81E‐03 | ACVR1,CDKN2A,RBL2 |
| VDR | Transcription regulator | 1.81E‐03 | ACACA,HIRA,PLCG1,RAD50,SLC34A2,THBD |
| FOXA2 | Transcription regulator | 1.92E‐03 | CDX2,FOXA2,GATA4,HNF1B,ISL1,SHH,SNAI1 |
| RBPJ | Transcription regulator | 2.08E‐03 | CDKN2A,EZH2,FGF4,GNA12,SOX4,TDGF1 |
| GSC | Transcription regulator | 2.20E‐03 | SHH,ZEB2 |
| TSG101 | Transcription regulator | 2.20E‐03 | TP53,TSG101 |
| PAX3 | Transcription regulator | 2.21E‐03 | ARC,ATF2,F2RL1,G6PD,RARRES2,SOX4,TP53 |
| NOTCH1 | Transcription regulator | 2.31E‐03 | CDK2,DLD,FLT1,MYCN,NOTCH1,RB1,SNAI1,TP53 |
| E2F6 | Transcription regulator | 2.40E‐03 | CDC7,DDX11,RAD51,RBBP8 |
| GFI1 | Transcription regulator | 2.46E‐03 | ATF2,CASP8,ISL1,RAF1,RB1 |
| BMP2 | Growth factor | 2.69E‐03 | BMPR2,CDK4,DLX3,IHH,NOTCH1,SMAD4,SPINT1 |
| FOXA1 | Transcription regulator | 2.81E‐03 | CDKN2A,CDX2,FOXA2,HNF1B,ISL1,SHH |
| TWIST1 | Transcription regulator | 3.00E‐03 | CDKN2A,EZH2,SHH,SNAI1,TP53,ZEB2 |
| KLF2 | Transcription regulator | 3.00E‐03 | APLNR,FLT1,GATA4,HIF1A,TBX5,THBD |
| SOX9 | Transcription regulator | 3.02E‐03 | CDK4,CDX2,COMMD3‐BMI1,IHH |
| JUN | Transcription regulator | 3.12E‐03 | CDKN2A,DICER1,DNMT1,FOXA2,GCLC,RASA1,SHH,SLC8A1,TP53,TXN,ZEB2 |
| EOMES | Transcription regulator | 3.14E‐03 | APLNR,EOMES,FOXA2,GSC,MESP1 |
| ATF4 | Transcription regulator | 3.29E‐03 | ABCA1,CDKN2A,HSP90B1,IHH,MCL1,XRCC1 |
| TGFB3 | Growth factor | 3.40E‐03 | CDKN2A,F2RL1,SMAD2,SNAI1,ZEB2 |
| TCF3 | Transcription regulator | 3.41E‐03 | AFDN,CDH5,CDK6,CDKN2A,HAND1,HSP90B1,MYCN,NOTCH1,PLK4 |
| RYBP | Transcription regulator | 3.49E‐03 | CDX2,GATA4 |
| MEOX1 | Transcription regulator | 3.49E‐03 | CDKN2A,GATA4 |
| BCL6B | Transcription regulator | 3.49E‐03 | CASP8,TP53 |
| TBX21 | Transcription regulator | 3.54E‐03 | CDK6,EOMES,TP53,ZEB2 |
| SP3 | Transcription regulator | 3.59E‐03 | ABCA1,DLX3,FLT1,MYCN,PCYT1A,TP53,TXNRD1 |
| YBX1 | Transcription regulator | 3.73E‐03 | CDK6,CDKN2A,SNAI1,TP53 |
| ETS2 | Transcription regulator | 3.73E‐03 | CDKN2A,CDX2,FLT1,RAF1 |
| ING1 | Transcription regulator | 3.85E‐03 | CDKN2A,SHH,TP53 |
| ZNF217 | Transcription regulator | 4.13E‐03 | EOMES,GATA4,MYCN,TDGF1 |
| TWIST2 | Transcription regulator | 4.17E‐03 | MYCN,SNAI1,ZEB2 |
| MAFF | Transcription regulator | 4.24E‐03 | GCLC,TXNRD1 |
| FOXD1 | Transcription regulator | 4.24E‐03 | ISL1,SHH |
| RUVBL2 | Transcription regulator | 4.24E‐03 | ATF2,TP53 |
| CDKN2C | Transcription regulator | 4.24E‐03 | CDKN2A,PTCH1 |
| HNF1B | Transcription regulator | 4.41E‐03 | ACVR1,FOXA2,IHH,SNAI1,ZEB2 |
| EGR3 | Transcription regulator | 4.51E‐03 | NF1,NOTCH1,PTPN11 |
| NGF | Growth factor | 4.59E‐03 | CDK2,CDKN2A,HTT,MYCN,RAC1,RBL2,TXN |
| STAT1 | Transcription regulator | 4.63E‐03 | ABCA1,CASP8,CDK2,HIF1A,ISL1,SHH,SLC8A1,SMAD2,TP53 |
| GATA3 | Transcription regulator | 4.70E‐03 | CDX2,DLX3,EOMES,NOTCH1,RAD50,TAL1,ZEB2 |
| FOSL1 | Transcription regulator | 4.78E‐03 | CDKN2A,GCLC,SNAI1,THBD |
| HSF2 | Transcription regulator | 4.87E‐03 | HIF1A,PSMC4,TXN |
| HIF1A | Transcription regulator | 4.89E‐03 | CDKN2A,FLT1,HIF1A,MCL1,NOTCH1,SHH,SNAI1,TBX5,TP53,TXN |
| NFE2L2 | Transcription regulator | 4.97E‐03 | ATF7,COPS5,CUL1,G6PD,GCLC,HSP90B1,PSMC3,TP53,TXN,TXNRD1 |
| BMP10 | Growth factor | 5.06E‐03 | BMPR2,TBX20 |
| NRG4 | Growth factor | 5.06E‐03 | ABCA1,ACACA |
| FOXD3 | Transcription regulator | 5.06E‐03 | EZH2,FOXA2 |
| HSF4 | Transcription regulator | 5.06E‐03 | FGF4,HIF1A |
| TFAP4 | Transcription regulator | 5.24E‐03 | CDK2,CDKN2A,SNAI1 |
| CARM1 | Transcription regulator | 5.24E‐03 | CDKN2A,CDX2,GCLC |
| MEN1 | Transcription regulator | 5.62E‐03 | CASP8,CDK4,EZH2 |
| CTCF | Transcription regulator | 5.74E‐03 | CDKN2A,GATA4,MYCN,TP53 |
| HDAC4 | Transcription regulator | 5.81E‐03 | ARC,CDKN2A,HIF1A,SLC8A1,SMAD4 |
| TLE1 | Transcription regulator | 5.94E‐03 | CDKN2A,MCL1 |
| SOX7 | Transcription regulator | 6.03E‐03 | DLX3,OTX2,SOX4 |
| EP300 | Transcription regulator | 6.72E‐03 | CDK2,CDKN2A,EP300,EPN1,NOTCH1,PARP1,PCYT1A,RAD51,RB1,TP53 |
| CBX2 | Transcription regulator | 6.89E‐03 | CDKN2A,GATA4 |
| VEGFB | Growth factor | 6.89E‐03 | CASP8,TP53,TXNRD1 |
| NFKBIA | Transcription regulator | 7.04E‐03 | ATF2,CASP8,CDK2,DAG1,EOMES,HIF1A,RAC1,SHH,SMAD4,TP53 |
| SKIL | Transcription regulator | 7.34E‐03 | FOXA2,GSC,TLN1 |
| ARNTL | Transcription regulator | 7.34E‐03 | ACACA,IHH,TP53 |
| ATN1 | Transcription regulator | 7.49E‐03 | GRK2,KAT2A,MAX,SOX11,SOX4 |
| MYOD1 | Transcription regulator | 7.75E‐03 | ACACA,CDK2,CDX2,DAG1,MYL1,RB1 |
| TBX3 | Transcription regulator | 7.90E‐03 | CDKN2A,TP53 |
| ACTN4 | Transcription regulator | 7.90E‐03 | MYCN,SNAI1 |
| KDM5B | Transcription regulator | 7.96E‐03 | COMMD3‐BMI1,GATA4,ISL1,SS18,TAL1 |
| SREBF1 | Transcription regulator | 8.01E‐03 | ABCA1,ACACA,CDK4,G6PD,MYL1,PCYT1A,TP53 |
| MYBL2 | Transcription regulator | 8.31E‐03 | CDK2,CDKN2A,FGF4 |
| ANGPT2 | Growth factor | 8.55E‐03 | GATA4,HIF1A,RDH10,SNAI1,TP53,XRCC1 |
| MTA1 | Transcription regulator | 8.81E‐03 | CDKN2A,EHMT2,SNAI1 |
| NDN | Transcription regulator | 8.98E‐03 | CDKN2A,RBL2 |
| GFM1 | Translation regulator | 9.04E‐03 | ARC |
| EEF1E1 | Translation regulator | 9.04E‐03 | TP53 |
| PSMD9 | Transcription regulator | 9.04E‐03 | SMAD2 |
| CITED4 | Transcription regulator | 9.04E‐03 | HIF1A |
| ZBTB48 | Transcription regulator | 9.04E‐03 | CDKN2A |
| GTF2E1 | Transcription regulator | 9.04E‐03 | TBP |
| DAZL | Translation regulator | 9.04E‐03 | CDK2 |
| SUPT4H1 | Transcription regulator | 9.04E‐03 | HTT |
| CAND1 | Transcription regulator | 9.04E‐03 | CUL1 |
| GTF2F1 | Transcription regulator | 9.04E‐03 | TBP |
| HOXD12 | Transcription regulator | 9.04E‐03 | SHH |
| RPS27L | Translation regulator | 9.04E‐03 | TP53 |
| ESX1 | Transcription regulator | 9.04E‐03 | KRAS |
| GPS2 | Transcription regulator | 9.34E‐03 | ABCA1,CDK6,SNX1 |
| ERG | Transcription regulator | 9.39E‐03 | EZH2,FLT1,MYCN,POU2F1,PTPN11,SOX4 |
| FGF8 | Growth factor | 9.76E‐03 | FGF4,LDB1,OTX2,SHH |
| FOSL2 | Transcription regulator | 9.88E‐03 | ABCA1,SOX4,TP53 |
| CTBP2 | Transcription regulator | 1.01E‐02 | CDH5,EOMES |
| DAXX | Transcription regulator | 1.01E‐02 | CASP8,SMAD4 |
| HDAC3 | Transcription regulator | 1.05E‐02 | BECN1,CDKN2A,G6PD,TBX5 |
| ZEB1 | Transcription regulator | 1.10E‐02 | CDKN2A,COMMD3‐BMI1,RBL2 |
| NOG | Growth factor | 1.10E‐02 | ISL1,PTCH1,SHH |
| YY2 | Transcription regulator | 1.13E‐02 | TDGF1,TP53 |
| MSTN | Growth factor | 1.16E‐02 | CDK2,HIF1A,MTOR |
| BMP6 | Growth factor | 1.17E‐02 | MYCN,SNAI1,TXNRD1,VCL |
| FMR1 | Translation regulator | 1.22E‐02 | ARC,DAG1,MTOR |
| COPS5 | Transcription regulator | 1.26E‐02 | HIF1A,TP53 |
| BRD7 | Transcription regulator | 1.26E‐02 | DICER1,RAD51 |
| NRF1 | Transcription regulator | 1.29E‐02 | GCLC,SDHD,TP53 |
| BACH2 | Transcription regulator | 1.29E‐02 | CDKN2A,MCL1,TP53 |
| ZNF202 | Transcription regulator | 1.39E‐02 | ABCA1,CDKN2A |
| EIF2S1 | Translation regulator | 1.39E‐02 | GCLC,MCL1 |
| NONO | Transcription regulator | 1.39E‐02 | ACACA,CDKN2A |
| NAB2 | Transcription regulator | 1.39E‐02 | FLT1,HIF1A |
| CTGF | Growth factor | 1.53E‐02 | HIF1A,LIMS1,SOX4,TP53 |
| SCX | Transcription regulator | 1.53E‐02 | SNAI1,TBX20 |
| MAF | Transcription regulator | 1.63E‐02 | RAD50,TP53,TXN |
| SALL4 | Transcription regulator | 1.67E‐02 | COMMD3‐BMI1,FGF4 |
| FOXC1 | Transcription regulator | 1.67E‐02 | MESP1,NOTCH1 |
| DKK1 | Growth factor | 1.71E‐02 | CDKN2A,TP53,TTYH1 |
| NRIP1 | Transcription regulator | 1.78E‐02 | ACACA,CDKN2A,SLC25A19 |
| EIF4B | Translation regulator | 1.80E‐02 | MCL1 |
| ALX1 | Transcription regulator | 1.80E‐02 | SNAI1 |
| HOXC5 | Transcription regulator | 1.80E‐02 | SHH |
| ADNP | Transcription regulator | 1.80E‐02 | TP53 |
| ZBTB49 | Transcription regulator | 1.80E‐02 | RB1 |
| VENTX | Transcription regulator | 1.80E‐02 | CDKN2A |
| ZNF326 | Transcription regulator | 1.80E‐02 | RAD50 |
| SNCAIP | Transcription regulator | 1.80E‐02 | TP53 |
| ZNF197 | Transcription regulator | 1.80E‐02 | HIF1A |
| BCLAF1 | Transcription regulator | 1.80E‐02 | TP53 |
| ARNTL2 | Transcription regulator | 1.80E‐02 | THBD |
| PREB | Transcription regulator | 1.80E‐02 | ABCA1 |
| ONECUT2 | Transcription regulator | 1.80E‐02 | FOXA2 |
| UHRF1 | Transcription regulator | 1.80E‐02 | RB1 |
| DDX20 | Transcription regulator | 1.80E‐02 | TP53 |
| HTATIP2 | Transcription regulator | 1.82E‐02 | SNAI1,TP53 |
| HEY1 | Transcription regulator | 1.97E‐02 | GATA4,TP53 |
| SMARCB1 | Transcription regulator | 2.02E‐02 | CDC7,CDKN2A,MCM10,PLK4,TP53 |
| LEF1 | Transcription regulator | 2.03E‐02 | CDKN2A,PTCH1,TP53 |
| GH1 | Growth factor | 2.06E‐02 | ACVR1,NRAS,SNAI1,XRCC1 |
| FOXL2 | Transcription regulator | 2.11E‐02 | CDKN2A,RSPO3,SOX4 |
| AIRE | Transcription regulator | 2.11E‐02 | BMP10,EOMES,MGAT1 |
| E2F5 | Transcription regulator | 2.13E‐02 | BECN1,MYCN |
| NODAL | Growth factor | 2.13E‐02 | CDK2,FGF4 |
| SOX6 | Transcription regulator | 2.13E‐02 | MYL1,TP53 |
| HEXIM1 | Transcription regulator | 2.13E‐02 | HIF1A,TP53 |
| NFIC | Transcription regulator | 2.13E‐02 | CDKN2A,TP53 |
| LEP | Growth factor | 2.14E‐02 | ACACA,ASB4,FLT1,GCLC,ISL1,MCL1,NOTCH1,RAC1,TP53 |
| HOXA9 | Transcription regulator | 2.21E‐02 | CDKN2A,HIRA,RAD51,SHH,SOX4 |
| DTX1 | Transcription regulator | 2.29E‐02 | MCL1,SNAI1 |
| SPDEF | Transcription regulator | 2.37E‐02 | HIF1A,SMAD2,SMAD4 |
| HOXA10 | Transcription regulator | 2.46E‐02 | FLT1,MAX,MYCN,THBD,TP53 |
| SP4 | Transcription regulator | 2.64E‐02 | ARC,FLT1 |
| NFIL3 | Transcription regulator | 2.64E‐02 | ACACA,EOMES |
| KLF6 | Transcription regulator | 2.66E‐02 | MCL1,PTCH1,SHH |
| THAP11 | Transcription regulator | 2.69E‐02 | GATA4 |
| SOX12 | Transcription regulator | 2.69E‐02 | FGF4 |
| TAF3 | Transcription regulator | 2.69E‐02 | GATA4 |
| OSR2 | Transcription regulator | 2.69E‐02 | OSR1 |
| LHX8 | Transcription regulator | 2.69E‐02 | ISL1 |
| GTF2F2 | Transcription regulator | 2.69E‐02 | TBP |
| SERTAD1 | Transcription regulator | 2.69E‐02 | CDK4 |
| GTF2H1 | Transcription regulator | 2.69E‐02 | TBP |
| ARID1B | Transcription regulator | 2.69E‐02 | ARC |
| HOXB2 | Transcription regulator | 2.69E‐02 | OTX2 |
| RPS14 | Translation regulator | 2.69E‐02 | TP53 |
| L3MBTL2 | Transcription regulator | 2.69E‐02 | CDC7 |
| SOX21 | Transcription regulator | 2.69E‐02 | CDX2 |
| ATF7IP | Transcription regulator | 2.69E‐02 | CDKN2A |
| VEZF1 | Transcription regulator | 2.69E‐02 | UBTF |
| CASP8AP2 | Transcription regulator | 2.69E‐02 | MCL1 |
| MXD3 | Transcription regulator | 2.69E‐02 | MYCN |
| FOS | Transcription regulator | 2.75E‐02 | DNMT1,GATA4,HSP90B1,Macf1,Nrg1,SNAI1,SUMO2,TAL1,TP53,TXN |
| MYB | Transcription regulator | 2.98E‐02 | NOTCH1,NRAS,SHH,SNAI1 |
| TCF7L1 | Transcription regulator | 3.00E‐02 | EOMES,FOXA2 |
| SOX10 | Transcription regulator | 3.00E‐02 | DAG1,NOTCH1 |
| MLXIPL | Transcription regulator | 3.00E‐02 | ACACA,HIF1A |
| NEUROG3 | Transcription regulator | 3.06E‐02 | ACACA,ISL1,XRCC1 |
| TFAP2C | Transcription regulator | 3.06E‐02 | CDX2,EOMES,RASA1 |
| IFI16 | Transcription regulator | 3.16E‐02 | CDKN2A,GATA4,XRCC1 |
| TBX2 | Transcription regulator | 3.16E‐02 | CDKN2A,DNMT1,EZH2 |
| CREB1 | Transcription regulator | 3.39E‐02 | ABCA1,ACVR2A,ARC,FLT1,MCL1,NF1,NOTCH1,PNO1,RB1,TXN |
| FGF16 | Growth factor | 3.57E‐02 | SNAI1 |
| PDLIM1 | Transcription regulator | 3.57E‐02 | SNAI1 |
| JDP2 | Transcription regulator | 3.57E‐02 | TP53 |
| HEY2 | Transcription regulator | 3.57E‐02 | GATA4,TBX5 |
| HLX | Transcription regulator | 3.57E‐02 | CDKN2A,RB1 |
| SUFU | Transcription regulator | 3.57E‐02 | PTCH1 |
| EAF2 | Transcription regulator | 3.57E‐02 | HIF1A |
| HOXC13 | Transcription regulator | 3.57E‐02 | CDKN2A |
| AES | Transcription regulator | 3.57E‐02 | FOXA2 |
| FOXH1 | Transcription regulator | 3.57E‐02 | FOXA2 |
| TBPL1 | Transcription regulator | 3.57E‐02 | NF1 |
| RAD21 | Transcription regulator | 3.57E‐02 | BMPR2,SOX4 |
| NFYB | Transcription regulator | 3.59E‐02 | AMD1,CDKN2A,GNA12,RAD51,SNAI1,UHRF1 |
| MRTFA | Transcription regulator | 3.60E‐02 | CDKN2A,RAC1,TAL1,VCL |
| CDX2 | Transcription regulator | 3.68E‐02 | CDX2,HNF1B,MYCN,SNAI1 |
| USF1 | Transcription regulator | 3.72E‐02 | ABCA1,CDK4,TP53 |
| IRF8 | Transcription regulator | 3.76E‐02 | ACVRL1,ATF7,NF1,TP53 |
| SOX17 | Transcription regulator | 3.78E‐02 | FOXA2,GATA4 |
| ETV4 | Transcription regulator | 3.78E‐02 | CDKN2A,SHH |
| EPAS1 | Transcription regulator | 3.82E‐02 | ACACA,FLT1,FXN,HIF1A,NOTCH1 |
| TBX5 | Transcription regulator | 3.83E‐02 | CDK2,GATA4,SLC8A1 |
| PIAS1 | Transcription regulator | 3.98E‐02 | ACACA,MCL1 |
| NFYA | Transcription regulator | 4.07E‐02 | COMMD3‐BMI1,NOTCH1,POU2F1 |
| YY1 | Transcription regulator | 4.17E‐02 | CDKN2A,DLX3,MYL1,RAD51,TP53,UHRF1 |
| GTF2B | Transcription regulator | 4.19E‐02 | RBBP8,TBP |
| XBP1 | Transcription regulator | 4.24E‐02 | ACACA,BECN1,HSP90B1,PCYT1A,TXN |
| ONECUT1 | Transcription regulator | 4.35E‐02 | ACVR1,CDK2,FOXA2,HNF1B,KAT7,TSG101 |
| MTDH | Transcription regulator | 4.40E‐02 | CASP8,HIF1A |
| PGF | Growth factor | 4.40E‐02 | FLT1,HIF1A |
| NFE2L1 | Transcription regulator | 4.40E‐02 | GCLC,PSMC3 |
| PRRX2 | Transcription regulator | 4.44E‐02 | SHH |
| TRIM29 | Transcription regulator | 4.44E‐02 | SNAI1 |
| SSBP2 | Transcription regulator | 4.44E‐02 | LDB1 |
| MTF2 | Transcription regulator | 4.44E‐02 | CDKN2A |
| RREB1 | Transcription regulator | 4.44E‐02 | CDKN2A |
| PHF6 | Transcription regulator | 4.44E‐02 | UBTF |
| TAF9 | Transcription regulator | 4.44E‐02 | TP53 |
| ELAVL4 | Translation regulator | 4.44E‐02 | MYCN |
| BRCA2 | Transcription regulator | 4.44E‐02 | TP53 |
| BRF1 | Transcription regulator | 4.44E‐02 | TBP |
| GTF2H4 | Transcription regulator | 4.44E‐02 | CDK4 |
| MYCL | Transcription regulator | 4.44E‐02 | CDK4 |
| Foxp2 | Transcription regulator | 4.44E‐02 | MYCN |
| Meis1 | Transcription regulator | 4.44E‐02 | HIF1A |
| MAX | Transcription regulator | 4.57E‐02 | CDK4,EZH2,RBBP8 |
| POU4F2 | Transcription regulator | 4.62E‐02 | OTX2,SHH |
| MYOCD | Transcription regulator | 4.70E‐02 | GATA4,HAND1,TP53 |
| ATF2 | Transcription regulator | 4.96E‐02 | CDKN2A,MCL1,NOTCH1 |