Table 1.

Fold changes (FC) of inflammatory cytokine and antimicrobial peptides measured with transdermal analysis patches, showing significant results after Benjamini–Hochberg correction for multiple testing

	HS lesional axilla vs. HS uninvolved upper arm			HS lesional axilla vs. HC axilla			HS uninvolved upper arm vs. HC upper arm			HS lesional groin vs. HS uninvolved thigh			HS lesional groin vs. HC groin			HS uninvolved thigh vs. HC thigh
	FC		P‐value	FC		P‐value	FC		P‐value	FC		P‐value	FC		P‐value	FC		P‐value
IL‐1α	0·53	↓	0·017^b	3·32		ns	0·99		ns	0·53		ns	1·02		ns	1·52		ns
IL‐1RA	0·48		ns	3·32	↑	0·027	0·70		ns	1·95		ns	15·20	↑	0·007	1·12		ns
IL‐8	20·91	↑^a	0·003^b	20·91	↑^a	0·007	ND		–	11·01	↑^a	0·003^c	11·01	↑^a	0·009	ND		–
IL‐12	ND		–	ND		–	ND		–	ND		–	ND		–	ND		–
IL‐17A	1·19		ns	16·59		0·011	9·22	↑	0·010	0·99		ns	2·25		ns	2·00		ns
IL‐23p19	0·69		ns	1·16		ns	1·18		ns	0·70	↓	0·027	0·92		ns	1·06		ns
CCL‐27	0·57		ns	1·00		ns	0·71		ns	1·00		ns	1·00		ns	1·00		ns
KLK‐5	1·47		ns	3·04		ns	1·85		ns	1·42		ns	2·80		ns	0·95		ns
hBD‐1	0·53	↓	0·006	0·50	↓	0·015	0·72		ns	1·34		ns	1·03		ns	0·53	↓	0·024
hBD‐2	5·43	↑	0·001	9·14	↑	0·022	1·68	↑	0·010	4·24	↑	< 0·001^d	8·30	↑	< 0·001	1·96	↑	0·011
hBD‐3	1·10		ns	1·24		ns	1·00		ns	1·09		ns	1·26	↑	ns	1·06		ns
hBD‐4	ND		–	ND		–	ND		–	ND		–	ND		–	ND		–

CCL‐27, C‐C motif chemokine ligand 27; hBD, human β‐defensin; HC, healthy control; HS, hidradenitis suppurativa; IL, interleukin; KLK, kallikrein‐related peptidase; ND, not detected in both groups; ns, not significant; bold, significant (P ≤ 0·05).

^aAnalysed using half of the lower limit of detection for one of the groups where data was under limit of detection; ^bmissing, n = 3; ^cmissing, n = 2; ^dmissing, n = 1.