. 2020 Nov 4;35(2):e23640. doi: 10.1002/jcla.23640

Table 4.

Diagnostic performance of APRI and FIB‐4 scores for ruling in cirrhosis

	Cutoff	Classifiable patients (% (n/N))	Specificity	Sensitivity	PPV	Misdiagnosis rate (% (n/N))	DOR	PLR
APRI	2.00 ^a	10.4% (45/433)	92.3%	18.3%	44.4%	7.7% (25/324)	2.7	2.4
FIB‐4	2.31 ^b	23.1% (100/433)	84.6%	45.9%	50.0%	15.4% (50/324)	4.6	3.0

Cutoff

Classifiable patients

(% (n/N))

Specificity

Sensitivity

PPV

Misdiagnosis rate

(% (n/N))

DOR

PLR

APRI

2.00 ^a

10.4% (45/433)

92.3%

18.3%

44.4%

7.7% (25/324)

2.7

2.4

FIB‐4

2.31 ^b

23.1% (100/433)

84.6%

45.9%

50.0%

15.4% (50/324)

4.6

3.0

Classifiable patients, the proportion of patients with APRI or FIB‐4 scores higher than the positive thresholds.

Abbreviations: DOR, diagnostic odds ratio; PLR, positive likelihood ratio; PPV, positive predictive value.

^{^a}

threshold calculated by 90% specificity ⁸ and recommended in various clinical guidelines and expert consensuses. ³ , ⁴ , ⁵ , ⁶ , ⁷

^{^b}

threshold calculated by 90% specificity. ⁸