Figure 3.

HIF‐1α/VEGF signaling pathway is important signaling pathway in the pro‐cancer effects of ANXA3 on melanoma. Heat map (A), Scale analysis diagram (B), refine results (C); Western blot for ANXA3/HIF‐1α/VEGF by over‐expression of ANXA3 (D) and ANXA3/HIF‐1α/VEGF by down‐regulation of ANXA3 (E), ANXA3/HIF‐1α/VEGF expression by over‐expression of ANXA3 (F‐H), ANXA3/HIF‐1α/VEGF expression by down‐regulation of ANXA3 (I‐K). Negative, negative group; ANXA3, 50 ng of ANXA3 group; siANXA3, 50 ng of siANXA3 group. **P < .01 versus negative group