Figure 1.

Virulence factors of P. aeruginosa target epithelial cell junctions during infection. The extracellular protease LasB released through T2SS temporarily blocks the binding of tight junction proteins. The quorum sensing system signal 3‐oxo‐C12‐HSL induces the removal of occludin phosphorylation. The secreted T3SS effectors ExoS, ExoT, ExoY, and ExoU act on the cytoskeleton. The secreted T6SS effector VgrG2b interacts with α‐tubulin, β‐tubulin, and the γ‐tubulin ring complex. PldA and PldB activate PI3K‐Akt signaling to infiltrate epithelial cells