Table 1.

The role of common bacterial pathogens in disrupting epithelial cell junctions during infection

Bacterial Pathogens	The role of bacterial pathogens during infection
Pseudomonas aeruginosa	Alter cytoskeletal structure and epithelial cell polarity; changing cell junction components to destruct the epithelial barrier integrity and increase mucosal permeability
Helicobacter pylori	Inhibition of actin‐mediated intracellular trafficking; interact with E‐cadherin to prevent formation of junctional complex; weaken the gastric epithelial barrier
Enteropathogenic Escherichia coli	Decreases transepithelial resistance of polarized cell monolayers; disrupt the formation of junctional complex; interrupt the migration of basolateral proteins to the apical membrane