TABLE 2.
Reproducibility and Reliability Based on the Manual Segmented SN Volumes of the NM‐MRI Sequences
| GRE MT on | TSE MT on | TSE MT off | |
|---|---|---|---|
| Mean volume mm3 (SD) | |||
| Rater 1 (test) | 355.52 (54.53) | 337.93 (64.73) | 328.15 (69.43) |
| Rater 1 (retest) | 373.91 (56.48) | 362.99 (67.62) | 306.11 (48.99) |
| Rater 2 (test) | 333.87 (35.48) | 343.10 (55.18) | 302.84 (42.80) |
| Rater 2 (retest) | 308.35 (36.73) | 340.14 (45.73) | 304.31 (37.37) |
| Rater 3 (test) | 365.56 (52.83) | 386.50 (42.14) | 378.63 (36.38) |
| Rater 3 (retest) | 391.11 (40.90) | 414.67 (40.96) | 380.67 (47.00) |
| Raters combined (test) | 351.65 (48.73) | 355.85 (57.49) | 336.54 (59.30) |
| Raters combined (retest) | 357.79 (57.03) | 372.50 (60.08) | 330.36 (56.41) |
| Test–retest variability (SD) | |||
| Rater 1 | 14.31% (13.08) | 10.74% (10.16) | 13.03% (12.76) |
| Rater 2 | 13.04% (10.68) | 10.99% (7.84) | 17.88% (9.82) |
| Rater 3 | 14.47% (12.05) | 11.47% (9.84) | 12.76% (7.83) |
| Test–retest ICC (95% CI) | |||
| Rater 1 | 0.13 (–0.48–0.66) | 0.73 (0.26–0.92) | 0.43 (–0.19–0.81) |
| Rater 2 | 0.05 (–0.54–0.61) | 0.57 (–0.11–0.86) | –0.13 (–0.66–0.48) |
| Rater 3 | –0.10 (–0.64–0.51) | 0.11 (–0.50–0.65) | –0.01 (–0.59–0.57) |
| Rater ICC (95% CI) | |||
| Intrarater ICC (R1) | 0.84 (0.67–0.93) | 0.87 (0.71–0.94) | 0.64 (0.32–0.83) |
| Intrarater ICC (R2) | 0.33 (–0.9–0.65) | 0.35 (–0.9–0.67) | 0.53 (0.17–0.77) |
| Intrarater ICC (R3) | 0.82 (0.30–0.94) | 0.72 (0.45–0.87) | 0.58 (0.12–0.81) |
| Interrater ICC | 0.11 (–0.07–0.36) | 0.34 (0.07–0.61) | 0.21 (–0.01–0.47) |
Given are the test–retest variability for each rater and ICC values with 95% confidence interval.
R1: rater 1; R2: rater 2; R3: rater 3; SD: standard deviation; ICC: intraclass correlation coefficient; 95% CI: 95% confidence interval; GRE: gradient recalled echo; MT: magnetization transfer pulse; TSE: turbo spin echo.