Figure 1.

Bar plots of median crizotinib and alectinib C_min per patient. (a) Median crizotinib C_min per patient. Each bar represents one patient. The dotted line indicates the threshold of 235 ng/mL. Twenty‐three patients (48%) have a pharmacokinetic exposure below this threshold. Interindividual and intraindividual variability were 45% and 20%, respectively. (b) Median alectinib C_min per patient. Each bar represents one patient. The dotted line indicates the threshold of 435 ng/mL. Nineteen patients (37%) have a pharmacokinetic exposure below this threshold. Interindividual and intraindividual variability were 57% and 27%, respectively. C_min, minimum plasma concentration. [Colour figure can be viewed at wileyonlinelibrary.com]