Figure 1.

Effect of pyrimethamine on the plasma concentrations, and amount excretion of metformin (a), and renal clearance (b). Plasma concentrations and urinary excretion of metformin were determined in the subjects treated with or without pyrimethamine (10, 25, and 75 mg). Each symbol represents the mean and SEM (n = 12). Urinary excretion during the intervals designated was shown in box‐and‐whisker plot. (b) Renal clearance determined in healthy volunteers treated with or without an oral dose of pyrimethamine (10, 25, and 75 mg) were shown in box‐and‐whisker plots. +PYR, pyrimethamine administrated group.