Figure 4.

Nonlinear regression analysis CL_r ratio of the test compounds and pyrimethamine C _av. K_{i ,app} of pyrimethamine with regard to C _av, and f _PYR were determined by iterative nonlinear regression analysis, as described in Methods. Rigid lines represent the fitted lines. The fitted parameters were summarized in Table 2 . 1‐NMN, N ¹‐methylnicotinamide; C_av, mean plasma concentration; CL_r, renal clearance; f _PYR, fraction sensitive to inhibition by pyrimethamine; K _i,app, apparent inhibition constant of pyrimethamine as the total concentration; PYR, pyrimethamine.