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. 2021 Jan 26;8:620459. doi: 10.3389/fcell.2020.620459

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Copyright © 2021 Kang, Larbi, Andrade, Reardon, Reh and Wohl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Müller glia miRNA expression after light damage. (A) Schematic of miRNA highly expressed in MG i.e., mGliomiRs and shared miRs (modified after Wohl and Reh, 2016). (B) Percent decline of the top 21 highly expressed MG miRNAs after 7 days light damage compared to normal MG (cutoff 3,000 counts). (C) miRNAs with similar declined levels after light damage as after Dicer deletion (in percent). (D) miRNAs with less declined levels after light damage as after Dicer deletion (in percent). (E) Fold increase of 5 miRNAs that increased after 7 days light damage (cutoff 5,000 counts) compared to controls. (F) DIANA-mirPath v.3 analysis of the 21 MG miRNAs that declined after light damage.