Figure 7.

Decline in Müller glia miRNAs does not affect Dicer or RISC. (A) DIANA-TarBase predicted/confirmed miRNAs regulating Dicer1, or members of the RNA-induced silencing complex (RISC) such as Argounate2 and or after Dicer deletion. (B) Expression levels (fold change of log₂ relative expression) of Dicer1, RISC genes, Glul and Gfap MG genes (reference) after light damage vs. controls (five and six biological replicates, respectively, one technical replicate per condition). (C) Expression levels (fold change of log₂ counts per million) from RNA-seq of Dicer1, Tnrc6a, Ago2, Glul, and Gfap after Dicer deletion vs. wild type (14 and 20 biological replicates respectively, one technical replicate per condition).