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. 2021 Feb 5;17(2):e1008982. doi: 10.1371/journal.ppat.1008982

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© 2021 Hansen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — Oxantel: free drawing after https://pubchem.ncbi.nlm.nih.gov/compound/oxantel#section=2D-Structure. Pyrantel: free drawing after https://pubchem.ncbi.nlm.nih.gov/compound/pyrantel#section=2D-Structure B: Dose-response curves for oxantel (oxa), pyrantel (pyr) and acetylcholine (ACh). The current response on Tsu-ACR-16-like receptor is normalised to current responses induced by 300 μM ACh and given as mean ± SEM. The EC₅₀ ± SD values were 9.48 ± 1.15 μM for oxa, 152.7 ± 1.20 μM for pyr and 14.5 ± 1.03 for ACh, the relative maximum current responses, I_max were 86.85 ± 4.63% and 29.41 ± 1.95%, and the Hill slope, n_H, 2.51 ± 1.30, 3.13 ± 1.07 and 2.14 ± 0.1 for oxa, pyr and ACh respectively.