Table II.
Results for primary models of time to pregnancy and infertility associations with TCDD exposure in the Seveso Women’s Health Study and their daughters born after the explosion, Seveso, Italy, 1976–2016.
| Time to pregnancy | Infertility | |
|---|---|---|
| fOR (95% CI) | RR (95% CI) | |
| SWHS | ||
| N | 446 | 98/464 |
| Initial 1976 TCDD | ||
| Unadjusted | 0.85 (0.72–1.01) | 1.29 (1.00–1.66) |
| Adjusteda | 0.82 (0.68–0.98) | 1.35 (1.01–1.79) |
| Estimated TCDD at pregnancy | ||
| Unadjusted | 0.92 (0.77–1.09) | 1.23 (0.87–1.73) |
| Adjusteda | 0.81 (0.66–0.99) | 1.27 (0.85–1.89) |
| Second generation daughters | ||
| N | 66 | 10 / 69 |
| Maternal initial 1976 TCDD | ||
| Unadjusted | 0.37 (0.25–0.55) | 1.57 (0.57–4.30) |
| Adjustedb | 0.59 (0.31–1.12) | 1.33 (0.66–2.67) |
| Estimated TCDD in utero | ||
| Unadjusted | 0.33 (0.21–0.53) | 1.72 (0.58–5.09) |
| Adjustedb | 0.59 (0.28–1.23) | 1.85 (0.82–4.19) |
fOR, fecundability odds ratio; RR, relative risk.
a
Models adjusted for maternal age at trying, smoking in previous year, oral contraceptive use in previous year, pre-explosion parity, irregular menstrual cycle, reproductive or endocrine conditions and paternal age.
b
Models adjusted for maternal and paternal age at trying, and maternal smoking in the previous year.