Table III.
Models of the relationship of initial 1976 TCDD and time to pregnancy stratified by genotype at each locus using dominant model of inheritance, Seveso Women’s Health Study (n = 442), Seveso, Italy, 1976–2016.
| 0 minor alleles | 1 or more alleles | ||||
|---|---|---|---|---|---|
| Gene | SNP | Adj-fOR (95% CI) | Adj-fOR (95% CI) | P int | FDR |
| AHR | rs2066853a | 0.77 (0.63–0.94) | 1.04 (0.69–1.58) | 0.19 | 0.81 |
| rs6968865a | 0.64 (0.45–0.92) | 0.91 (0.74–1.11) | 0.09 | 0.81 | |
| AHRR | rs10044468a | 0.88 (0.72–1.08) | 0.61 (0.40–0.92) | 0.12 | 0.81 |
| rs11746079a | 0.85 (0.69–1.04) | 0.53 (0.33–0.85) | 0.08 | 0.81 | |
| rs17562461a | 0.93 (0.73–1.20) | 0.71 (0.54–0.92) | 0.13 | 0.81 | |
| rs2015774a | 0.77 (0.64–0.93) | 1.10 (0.70–1.74) | 0.14 | 0.81 | |
| CYP1A1 | rs4646903a | 0.87 (0.72–1.05) | 0.62 (0.39–0.98) | 0.17 | 0.81 |
| CYP1B1 | rs1056836a | 0.71 (0.52–0.96) | 0.91 (0.72–1.14) | 0.19 | 0.81 |
| rs162549 | 0.75 (0.59–0.94) | 0.96 (0.72–1.27) | 0.18 | 0.81 | |
| rs163080a | 0.74 (0.59–0.93) | 0.98 (0.74–1.30) | 0.13 | 0.81 |
Models adjusted for maternal age at trying, smoking in previous year, oral contraceptive use in previous year, pre-explosion parity, irregular menstrual cycle, history of reproductive or endocrine conditions and paternal age.
AHR, aryl hydrocarbon receptor; AHRR, aryl hydrocarbon receptor repressor; CYP, cytochrome P450; FDR, false discovery rate; Pint, P-value for interaction; SNP, single-nucleotide polymorphism.
a
Included in genetic risk allele score calculation.