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. 2020 Dec 24;36(3):771–784. doi: 10.1093/humrep/deaa300

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© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Maturation and chromosomal misalignment rates of oocytes isolated from mice at different ages. (A) Maturation rates after in-vitro culture. (B) Percentage of oocytes with one or more misaligned chromosomes. (C) Representative images of MII oocytes with labeled spindles (green) and DNA (red). Mo, month. Results are presented from at least three replicate experiments in all cases. Error bars show SE of the mean. Number of oocytes analyzed in each group are shown. **P ≤ 0.01; ***P ≤ 0.001 and NS, not significant.