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. 2020 Dec 24;36(3):771–784. doi: 10.1093/humrep/deaa300

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© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Generation of reactive oxygen species (ROS)-induced model of spindle and chromosomal defects. Germinal vesicle (GV) stage oocytes were collected from 1 month (1-Mo) and 18-Mo-old mice and were matured in vitro in M2 medium. (A) Metaphase II (MII) oocytes in 1-Mo group either remained in M2 medium or were treated with 25 µM H₂O₂ for 1 h. The 18-Mo group MII oocytes remained untreated. Mature oocytes were fixed and labeled for spindles (green) and DNA (red). (B) Percentage of oocytes containing aligned or misaligned chromosomes in different groups. Number of oocytes analyzed in each group are shown. ***P ≤ 0.001 and NS, not significant.