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. 2020 Dec 24;36(3):771–784. doi: 10.1093/humrep/deaa300

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© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Enhanced mitochondrial membrane potential (MMP) and oocyte maturation rates by mitochondria-targeted agents. (A) H₂O₂ significantly decreased MMP but BGP-15 or MitoQ can prevent such decrease in MMP in metaphase II (MII) oocytes from 1 month (1-Mo) old mice. (B) Comparison MMP in MII oocytes from young (1-Mo) and old (18-Mo) mice after IVM in the absence or presence of BGP-15, MitoQ and both combined. Number of oocytes analyzed in each group are shown. (C) Comparison of maturation rates of oocytes from young (1-Mo) and old (18-Mo) mice after in-vitro culture in the absence or presence of BGP-15, MitoQ and both combined. Error bars show SE of the mean. Number of oocytes analyzed in each group are shown. **P ≤ 0.01, ****P ≤ 0.0001.