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Possible mechanistic routes, in which melatonin could affect the infection process. Serious inflammation, oxidation, and an over-reactive immune system response contribute to COVID-19 pathology, leading to a cytokine storm causing ALI/ARDS, and frequently death, which could be reduced by the administration of melatonin. ALI, acute lung injury; ARDS, respiratory distress syndrome; ss, single strand; MLT, melatonin.
