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. 2021 Feb 1;47(4):32. doi: 10.3892/ijmm.2021.4865

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Copyright: © Turrubiates-Hernández et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Vitamin D metabolism. Vitamin D is obtained through diet or skin synthesis by sun exposure and is converted to calcidiol in the liver. Subsequently, a second hydroxylation in the kidneys transforms calcidiol into calcitriol (active form of vitamin D). Calcitriol binds to the VDR and forms a complex with the RXR to regulate gene transcription. 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D; VDR, vitamin D receptor; RXR, retinoid-X receptor; VDREs, vitamin D response elements; PTH, parathyroid hormone; 24-OHase, 25-hydroxyvitamin D-24-hydroxylase. The figure was created using BioRender (https://biorender.com/).