Table 2.
Comparison of effect estimates of tumor necrosis factor (TNF) proteins on risk of earl progressive renal decline (PRD) between Macro- and Micro-Albuminuria Studies.
| Macro-Albuminuria Study Risk of ESKD 15years n= 198 |
Micro-Albuminuria Study eGFR loss ≥3 ml/min/year n= 148 |
||||
|---|---|---|---|---|---|
| Gene Name | Protein name | OR | FDR | OR | P value |
| TNF receptors associated with the both outcome | |||||
| TNF-R1A | TNF-R1 | 1.79 | <.0001 | 1.64 | 0.0015 |
| TNF-R1B | TNF-R2 | 1.80 | <.0001 | 1.86 | 0.0001 |
| TNF-R3 | LTBR | 1.92 | <.0001 | 1.46 | 0.0140 |
| TNF-R4 | OX40 | 1.66 | <.0001 | 1.64 | 0.0017 |
| TNF-R6 | FAS | 1.37 | 0.0249 | 1.49 | 0.0090 |
| TNF-R6B | DcR3 | 1.96 | <.0001 | 1.56 | 0.0043 |
| TNF-R7 | CD27 | 1.87 | <.0001 | 1.73 | 0.0006 |
| TNF-R10A | TRAIL-R1 | 1.90 | <.0001 | 1.61 | 0.0024 |
| TNF-R10B | TRAIL-R2 | 2.43 | <.0001 | 1.40 | 0.0290 |
| TNF-R11A | RANK | 2.07 | <.0001 | 1.43 | 0.0200 |
| TNF-R14 | HVEM | 1.94 | <.0001 | 1.60 | 0.0024 |
| TNF-R21 | DR6 | 1.47 | 0.0066 | 1.49 | 0.0100 |
| TNF-R27 | EDA2R | 1.98 | <.0001 | 1.45 | 0.0150 |
| TNF Receptors inconsistent associations | |||||
| TNF-R10C | TRAIL-R3 | 1.21 | 0.1672 | 1.22 | 0.1900 |
| TNF-R11B | OPG | 1.19 | 0.2155 | 1.36 | 0.0410 |
| TNF-R12A | TWEAKR | 1.76 | 0.0002 | 1.24 | 0.1600 |
| TNF-R13B | TACI | 1.51 | 0.0038 | 1.30 | 0.0820 |
| TNF-R19 | TROY | 2.03 | <.0001 | 1.29 | 0.0890 |
| TNF-R19L | RELT | 1.90 | <.0001 | 1.24 | 0.1400 |
| Findings for TNF ligands | |||||
| TNF-L5 | CD40-L | 1.23 | 0.1575 | 0.93 | 0.6300 |
| TNF-L6 | FASLG | 1.24 | 0.1394 | 1.13 | 0.4100 |
| TNF-L7 | CD70 | 1.21 | 0.1816 | 1.39 | 0.0320 |
| TNF-L10 | TRAIL | 1.17 | 0.2401 | 1.36 | 0.0460 |
| TNF-L13 | APRIL | 1.19 | 0.2167 | 1.18 | 0.2700 |
| TNF-L13B | BAFF | 1.12 | 0.3812 | 1.33 | 0.0580 |
Odds ratio (OR) was estimated as one quartile change in baseline concentration of TNF proteins and stratified by each batch in order to consider the inter-variation between batches. False discovery rate (FDR) of q value <0.05 in the Macro-albuminuria Study and nominal p value <0.05 in the Micro-Albuminuria Study were considered as statistical significance. eGFR, estimated glomerular filtration rate. ESKD, end-stage kidney disease.