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. Author manuscript; available in PMC: 2021 Feb 18.
Published in final edited form as: Nat Chem Biol. 2020 Aug 3;17(1):20–29. doi: 10.1038/s41589-020-0604-z

Extended Data Fig. 8. Bile acid concentrations in cecal contents of mice gavaged chronically with CA7S.

Extended Data Fig. 8

Cecal contents were collected from mice following an overnight fast after 48 days of daily gavage with CA7S or PBS. Bile acids were quantified using UPLC-MS (n=7 in each group, data not marked with asterisk(s) are not significant). All bile acids with measurable concentrations above the limit of detection are shown. Total BAs without CA7S, p=0.82; Total bile acids (BAs), p=0.38; Tα/βMCA, tauro-alpha- and tauro-beta-muricholic acid, p=0.46; TωMCA, tauro-omega-muricholic acid, p=0.12; TγMCA, tauro-gamma-muricholic acid, p=0.23; TCA, tauro-cholic acid, p=0.09; TUDCA, tauro-ursodeoxycholic acid, p=0.76; TCDCA, tauro-chenodeoxycholic acid, p=0.17; αβMCA, alpha-muricholic acid and beta-muricholic acid, p=0.23; CA, cholic acid, p=0.06; TDCA, tauro-deoxycholic acid, p=0.71; UDCA, ursodeoxycholic acid, *p=0.01; CDCA, chenodeoxycholic acid, p=0.06; DCA, deoxycholic acid, p=0.23; LCA, lithocholic acid, *p=0.04; 3-oxo-CA, 3-oxo-cholic acid, p=0.30, two-tailed Welch’s t-test. All data are presented as mean ± SEM.