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. 2021 Feb 18;10:e62273. doi: 10.7554/eLife.62273

Table 2. Enriched GO terms for the synaptic genes dysregulated in the cerebellum and spinal cord in WNV-ND.

GO term ID GO domain GO term name - hierarchical structure Q-value
Spinal cord Cerebellum
GO:0045202 CC synapse 7.13E-113 3.56E-35
GO:0097060 CC ├─ synaptic membrane 6.07E-03
GO:0098793 CC ├─ presynapse 4.20E-51 4.19E-17
GO:0099523 CC │ ├─ presynaptic cytosol 7.07E-05 1.79E-03
GO:0048786 CC │ ├─ presynaptic active zone 1.52E-15
GO:0048787 CC │  │ └─ presynaptic active zone membrane 3.25E-11 1.08E-06
GO:0098833 CC │ ├─ presynaptic endocytic zone 6.87E-03
GO:0008021 CC │ ├─ synaptic vesicle 6.06E-05
GO:0098992 CC │ ├─ neuronal dense core vesicle 4.44E-03
GO:0042734 CC │ ├─ presynaptic membrane 4.46E-21 3.52E-10
GO:0043083 CC ├─synaptic cleft 5.66E-07 2.40E-05
GO:0098794 CC ├─ postsynapse 5.38E-80 4.68E-24
GO:0099524 CC │ ├─ postsynaptic cytosol 1.61E-02
GO:0099571 CC │ ├─ postsynaptic cytoskeleton 2.60E-05
GO:0099572 CC │ ├─ postsynaptic specialization 4.46E-44 4.94E-11
GO:0014069 CC │  │ ├─ postsynaptic density 1.73E-34 3.60E-08
GO:0045211 CC │ ├─ postsynaptic membrane 1.12E-21 6.60E-10
SYNGO:postsyn_ser CC │  └─ postsynaptic SER 3.30E-04
SYNGO:synprocess BP process in the synapse 1.30E-87 2.74E-35
SYNGO:presynprocess BP ├─ process in the presynapse 4.96E-21 4.11E-07
GO:0099509 BP │ ├─ regulation of presynaptic cytosolic calcium levels 7.25E-04
GO:0099504 BP │ ├─ synaptic vesicle cycle 5.53E-21 2.01E-04
GO:0016079 BP │  │ ├─ synaptic vesicle exocytosis 9.78E-13 3.58E-03
GO:0099502 BP │  │ │ ├─ calcium-dependent activation of synaptic vesicle fusion 4.74E-04
GO:2000300 BP │  │ │ ├─ regulation of synaptic vesicle exocytosis 1.82E-04
GO:0016082 BP │  │ │ └─ synaptic vesicle priming 4.88E-05
GO:0048488 BP │  │ └─ synaptic vesicle endocytosis 6.15E-06
SYNGO:postsynprocess BP ├─ process in the postsynapse 5.44E-17 8.45E-06
GO:0099566 BP │ ├─ regulation of postsynaptic cytosolic calcium levels 2.92E-03
GO:0060078 BP │ ├─ regulation of postsynaptic membrane potential 2.75E-07 1.63E-03
GO:0099072 BP │ ├─ regulation of postsynaptic membrane neurotransmitter receptor levels 6.34E-08 1.10E-02
GO:0099645 BP │  │ ├─ neurotransmitter receptor localization to postsynaptic specialization membrane 1.70E-05
GO:0099149 BP │  │ └─ regulation of postsynaptic neurotransmitter receptor endocytosis 9.33E-05
GO:0099537 BP │ ├─ trans-synaptic signaling 1.47E-20 8.11E-13
GO:0007268 BP │  │ └─ chemical synaptic transmission 1.11E-17 1.43E-10
GO:0050804 BP │  │ ├─ modulation of chemical synaptic transmission 8.44E-11 1.63E-07
GO:0099171 BP │  │ │ └─ presynaptic modulation of chemical synaptic transmission 9.43E-05 7.08E-04
GO:0099170 BP │  │  └─ postsynaptic modulation of chemical synaptic transmission 2.89E-04
GO:0050808 BP ├─ synapse organization 4.53E-45 4.99E-14
GO:0099173 BP │ ├─ postsynapse organization 5.47E-15 1.91E-02
GO:0099010 BP │  │ └─ modification of postsynaptic structure 1.92E-05
GO:0099181 BP │  │ ├─ structural constituent of presynapse 1.46E-06
GO:0098882 BP │  │ │ ├─ structural constituent of active zone 9.80E-06
GO:0099186 BP │  │ └─ structural constituent of postsynapse 2.40E-03
GO:0099560 BP │ ├─ synapse adhesion between pre- and post-synapse 8.52E-06 4.79E-03
GO:0007416 BP │ ├─ synapse assembly 1.75E-10 2.01E-04
GO:0099054 BP │  │ ├─ presynapse assembly 8.02E-03
GO:0051963 BP │  │ ├─ regulation of synapse assembly 4.99E-07 1.19E-04
GO:1905606 BP │  │ │ ├─ regulation of presynapse assembly 1.37E-04 2.76E-04
GO:0097107 BP │  │ │ └─ postsynaptic density assembly 1.03E-02
GO:0060074 BP │ ├─ synapse maturation 6.28E-05
GO:0099188 BP │  └─ postsynaptic cytoskeleton organization 2.89E-04 1.46E-03
SYNGO:metabolism BP ├─ metabolism 1.69E-02
SYNGO:catabolic_postsynapse BP │  │ └─ protein catabolic process at postsynapse 2.40E-03
SYNGO:transport BP └─ transport 1.48E-03
GO:0098887 BP │  └─ neurotransmitter receptor transport, endosome to postsynaptic membrane 2.40E-03

Note: The top-level GO terms 'synapse' and 'process in the synapse' and major successive terms for synaptic subcompartments and processes are highlighted for the cerebellum and spinal cord at the advanced-symptomatic stage of WNV-ND. CC, cellular component; BP, biological process.