Table 2. Enriched GO terms for the synaptic genes dysregulated in the cerebellum and spinal cord in WNV-ND.
GO term ID | GO domain | GO term name - hierarchical structure | Q-value | |
---|---|---|---|---|
Spinal cord | Cerebellum | |||
GO:0045202 | CC | synapse | 7.13E-113 | 3.56E-35 |
GO:0097060 | CC | ├─ synaptic membrane | 6.07E-03 | |
GO:0098793 | CC | ├─ presynapse | 4.20E-51 | 4.19E-17 |
GO:0099523 | CC | │ ├─ presynaptic cytosol | 7.07E-05 | 1.79E-03 |
GO:0048786 | CC | │ ├─ presynaptic active zone | 1.52E-15 | |
GO:0048787 | CC | │ │ └─ presynaptic active zone membrane | 3.25E-11 | 1.08E-06 |
GO:0098833 | CC | │ ├─ presynaptic endocytic zone | 6.87E-03 | |
GO:0008021 | CC | │ ├─ synaptic vesicle | 6.06E-05 | |
GO:0098992 | CC | │ ├─ neuronal dense core vesicle | 4.44E-03 | |
GO:0042734 | CC | │ ├─ presynaptic membrane | 4.46E-21 | 3.52E-10 |
GO:0043083 | CC | ├─synaptic cleft | 5.66E-07 | 2.40E-05 |
GO:0098794 | CC | ├─ postsynapse | 5.38E-80 | 4.68E-24 |
GO:0099524 | CC | │ ├─ postsynaptic cytosol | 1.61E-02 | |
GO:0099571 | CC | │ ├─ postsynaptic cytoskeleton | 2.60E-05 | |
GO:0099572 | CC | │ ├─ postsynaptic specialization | 4.46E-44 | 4.94E-11 |
GO:0014069 | CC | │ │ ├─ postsynaptic density | 1.73E-34 | 3.60E-08 |
GO:0045211 | CC | │ ├─ postsynaptic membrane | 1.12E-21 | 6.60E-10 |
SYNGO:postsyn_ser | CC | │ └─ postsynaptic SER | 3.30E-04 | |
SYNGO:synprocess | BP | process in the synapse | 1.30E-87 | 2.74E-35 |
SYNGO:presynprocess | BP | ├─ process in the presynapse | 4.96E-21 | 4.11E-07 |
GO:0099509 | BP | │ ├─ regulation of presynaptic cytosolic calcium levels | 7.25E-04 | |
GO:0099504 | BP | │ ├─ synaptic vesicle cycle | 5.53E-21 | 2.01E-04 |
GO:0016079 | BP | │ │ ├─ synaptic vesicle exocytosis | 9.78E-13 | 3.58E-03 |
GO:0099502 | BP | │ │ │ ├─ calcium-dependent activation of synaptic vesicle fusion | 4.74E-04 | |
GO:2000300 | BP | │ │ │ ├─ regulation of synaptic vesicle exocytosis | 1.82E-04 | |
GO:0016082 | BP | │ │ │ └─ synaptic vesicle priming | 4.88E-05 | |
GO:0048488 | BP | │ │ └─ synaptic vesicle endocytosis | 6.15E-06 | |
SYNGO:postsynprocess | BP | ├─ process in the postsynapse | 5.44E-17 | 8.45E-06 |
GO:0099566 | BP | │ ├─ regulation of postsynaptic cytosolic calcium levels | 2.92E-03 | |
GO:0060078 | BP | │ ├─ regulation of postsynaptic membrane potential | 2.75E-07 | 1.63E-03 |
GO:0099072 | BP | │ ├─ regulation of postsynaptic membrane neurotransmitter receptor levels | 6.34E-08 | 1.10E-02 |
GO:0099645 | BP | │ │ ├─ neurotransmitter receptor localization to postsynaptic specialization membrane | 1.70E-05 | |
GO:0099149 | BP | │ │ └─ regulation of postsynaptic neurotransmitter receptor endocytosis | 9.33E-05 | |
GO:0099537 | BP | │ ├─ trans-synaptic signaling | 1.47E-20 | 8.11E-13 |
GO:0007268 | BP | │ │ └─ chemical synaptic transmission | 1.11E-17 | 1.43E-10 |
GO:0050804 | BP | │ │ ├─ modulation of chemical synaptic transmission | 8.44E-11 | 1.63E-07 |
GO:0099171 | BP | │ │ │ └─ presynaptic modulation of chemical synaptic transmission | 9.43E-05 | 7.08E-04 |
GO:0099170 | BP | │ │ └─ postsynaptic modulation of chemical synaptic transmission | 2.89E-04 | |
GO:0050808 | BP | ├─ synapse organization | 4.53E-45 | 4.99E-14 |
GO:0099173 | BP | │ ├─ postsynapse organization | 5.47E-15 | 1.91E-02 |
GO:0099010 | BP | │ │ └─ modification of postsynaptic structure | 1.92E-05 | |
GO:0099181 | BP | │ │ ├─ structural constituent of presynapse | 1.46E-06 | |
GO:0098882 | BP | │ │ │ ├─ structural constituent of active zone | 9.80E-06 | |
GO:0099186 | BP | │ │ └─ structural constituent of postsynapse | 2.40E-03 | |
GO:0099560 | BP | │ ├─ synapse adhesion between pre- and post-synapse | 8.52E-06 | 4.79E-03 |
GO:0007416 | BP | │ ├─ synapse assembly | 1.75E-10 | 2.01E-04 |
GO:0099054 | BP | │ │ ├─ presynapse assembly | 8.02E-03 | |
GO:0051963 | BP | │ │ ├─ regulation of synapse assembly | 4.99E-07 | 1.19E-04 |
GO:1905606 | BP | │ │ │ ├─ regulation of presynapse assembly | 1.37E-04 | 2.76E-04 |
GO:0097107 | BP | │ │ │ └─ postsynaptic density assembly | 1.03E-02 | |
GO:0060074 | BP | │ ├─ synapse maturation | 6.28E-05 | |
GO:0099188 | BP | │ └─ postsynaptic cytoskeleton organization | 2.89E-04 | 1.46E-03 |
SYNGO:metabolism | BP | ├─ metabolism | 1.69E-02 | |
SYNGO:catabolic_postsynapse | BP | │ │ └─ protein catabolic process at postsynapse | 2.40E-03 | |
SYNGO:transport | BP | └─ transport | 1.48E-03 | |
GO:0098887 | BP | │ └─ neurotransmitter receptor transport, endosome to postsynaptic membrane | 2.40E-03 |
Note: The top-level GO terms 'synapse' and 'process in the synapse' and major successive terms for synaptic subcompartments and processes are highlighted for the cerebellum and spinal cord at the advanced-symptomatic stage of WNV-ND. CC, cellular component; BP, biological process.