Table 3. Enriched GO terms for the upregulated or downregulated synaptic genes in WNV-infected cerebellum and spinal cord.
| Number of upregulated genes (percent) |
Enriched GO terms | Number of downregulated genes (percent) |
Enriched GO terms | |
| Early-symptomatic | ||||
| Cerebellum | 24 (80%) | postsynaptic specialization | 6 (20%) | presynapse |
| Spinal cord | 44 (51.2%) | presynapse; postsynapse; postsynaptic specialization; synapse organization; synapse assembly; chemical synaptic transmission | 42 (48.8%) | postsynapse; postsynaptic specialization; synapse organization; regulation of postsynaptic membrane neurotransmitter receptor levels; modulation of chemical synaptic transmission |
| Advanced-symptomatic | ||||
| Cerebellum | 67 (45.9%) | synapse organization; regulation of synapse assembly; presynaptic active zone membrane; presynaptic modulation of chemical synaptic transmission; postsynaptic specialization; metabolism | 79 (54.1%) | regulation of synapse organization; regulation of presynapse assembly; presynaptic cytosol; presynaptic active zone membrane; regulation of presynaptic membrane potential; postsynaptic actin cytoskeleton organization; postsynaptic specialization; regulation of postsynaptic membrane neuro-transmitter receptor levels; regulation of postsynaptic membrane potential; synapse adhesion between pre- and postsynapse; regulation of synaptic vesicle cycle; modulation of chemical synaptic transmission |
| Spinal cord | 109 (28.5%) | synapse organization; regulation of synapse assembly; synaptic vesicle membrane; synapse adhesion between pre- and post-synapse; synaptic cleft; presynaptic active zone membrane; presynaptic modulation of chemical synaptic transmission; postsynaptic specialization; synaptic vesicle cycle; modulation of chemical synaptic transmission | 274 (71.5%) | regulation of synapse organization; synaptic vesicle membrane; neuronal dense core vesicle; regulation of synaptic vesicle cycle; synaptic vesicle neurotransmitter loading; synaptic vesicle priming; synapse adhesion between pre- and postsynapse; synaptic cleft; structural constituent of presynapse; presynaptic cytosol; presynaptic active zone cytoplasmic component; presynaptic active zone membrane; presynaptic endocytic zone; regulation of presynapse assembly; regulation of presynaptic cytosolic calcium levels; regulation of presynaptic membrane potential; presynaptic modulation of chemical synaptic transmission; structural constituent of postsynapse; regulation of postsynapse organization; postsynaptic cytosol; regulation of modification of postsynaptic actin cytoskeleton; modification of postsynaptic structure; postsynaptic specialization assembly; regulation of postsynaptic cytosolic calcium levels; regulation of calcium-dependent activation of synaptic vesicle fusion; protein catabolic process at postsynapse; regulation of postsynaptic membrane neurotransmitter receptor levels; regulation of postsynaptic neurotransmitter receptor activity; regulation of postsynaptic membrane potential; postsynaptic modulation of chemical synaptic transmission; transport; metabolism |