Table 4. Neuronal cell compartments and neural functions controlled by West Nile virus (WNV)-induced immune-neural pleiotropic differentially expressed genes (DEGs).
| GO domain |
GO term | No. of genes | Gene symbols |
|---|---|---|---|
| Cerebellum | |||
| CC | somatodendritic compartment (GO:0036477) | 19 | MBP, HCLS1, ITGA4, PTX3, FCGR2B, ZBP1, CCR2, CYFIP1, CTSL2, CIB1, AIF1, SOS1, ANXA3, CD3E, S100B, FLNA, MAPK1, ITGA1, TGFB2 |
| CC | neuron projection (GO:0043005) | 19 | MBP, EPHA2, HCLS1, ITGA4, FCGR2B, ZBP1, VIM, CCR2, BCL11B, CYFIP1, CTSL2, CIB1, ANXA3, CD3E, FLNA, MAPK1, ITGA1, TGFB2, ODZ1 |
| CC | postsynapse (GO:0098794) | 11 | JAK2, HCLS1, C1QA, FCGR2B, ZBP1, CYFIP1, STAT3, SOS1, CD3E, FLNA, MAPK1 |
| BP | neuron projection development (GO:0031175) | 25 | EPHA2, JAK2, IL6, HCLS1, ITGA4, ADM, RHOG, SHC1, BCL11B, CYFIP1, SDC4, LST1, DOK2, CXCR4, SEMA4A, CSF1R, SOS1, CD3E, S100B, HMGB1, GATA3, MAPK1, CXCL12, ITGA1, NCKAP1L |
| BP | positive regulation of neuron death (GO:1901216) | 13 | PTX3, C1QA, FCGR2B, IFNG, BAX, TYROBP, TNF, BCL2L11, GRN, TLR4, ITGA1, TGFB2, CCL3 |
| BP | microglial cell activation (GO:0001774) | 10 | JAK2, C1QA, IFNG, TLR2, TYROBP, TNF, FPR2, AIF1, GRN, C5AR1 |
| BP | astrocyte activation (GO:0048143) | 7 | C1QA, IFNG, TNF, FPR2, IL1B, GRN, C5AR1 |
| BP | glial cell migration (GO:0008347) | 4 | P2RY12, CCL2, TGFB2, CCL3 |
| BP | axon guidance (GO:0007411) | 12 | EPHA2, RHOG, SHC1, BCL11B, CYFIP1, DOK2, CXCR4, CSF1R, SOS1, GATA3, MAPK1, CXCL12 |
| BP | postsynapse to nucleus signaling pathway (GO:0099527) | 3 | JAK2, STAT3, RELA |
| BP | regulation of synapse structure or activity (GO:0050803) | 8 | HCLS1, FCGR2B, TLR2, SEMA4D, CYFIP1, TNF, SLC7A11, SEMA4A |
| BP | positive regulation of glutamate receptor signaling pathway (GO:1900451) | 3 | IFNG, CCR2, CCL2 |
| BP | synapse pruning (GO:0098883) | 2 | C1QA, C3 |
| Spinal cord | |||
| CC | somatodendritic compartment (GO:0036477) | 39 | REG1A, HSP90AA1, HCLS1, DAB2IP, DHX36, ITGA4, PTX3, FCGR2B, ZBP1, CX3CL1, BCR, HSP90AB1, PTK2B, RARA, FZD3, PSEN1, CCR2, APP, CASP3, PAFAH1B1, DOCK10, ALCAM, ARHGEF7, CTSL2, CIB1, AIF1, PTK2, P2RX4, RTN4, KIF5B, PURA, ADAM10, SNAP25, DNM2, FLNA, MAPK1, NEDD4, BECN1, ITGA1 |
| CC | neuron projection (GO:0043005) | 46 | REG1A, EPHA2, HSP90AA1, HCLS1, DAB2IP, DHX36, ITGA4, FCGR2B, ZBP1, CX3CL1, BCR, HSP90AB1, PTK2B, RARA, FZD3, PSEN1, VIM, CCR2, APP, LRRC7, BSG, PAFAH1B1, DOCK10, ALCAM, ARHGEF7, CTSL2, CIB1, ARF1, PTK2, ITGA3, CYFIP2, P2RX4, KIF5B, PURA, ADAM10, NCAM1, SNAP25, DNM2, FLNA, MAPK1, NEDD4, BECN1, ITGA1, CEP290, ODZ1, BRAF |
| CC | axon (GO:0030424) | 25 | REG1A, HSP90AA1, DAB2IP, DHX36, ITGA4, ZBP1, BCR, HSP90AB1, PTK2B, FZD3, PSEN1, APP, LRRC7, BSG, PAFAH1B1, ALCAM, CIB1, ITGA3, P2RX4, KIF5B, ADAM10, SNAP25, DNM2, FLNA, MAPK1 |
| CC | synapse (GO:0045202) | 37 | HCLS1, C1QA, FCGR2B, ZBP1, RAB35, BCR, PTK2B, FZD3, PSEN1, FZD3, NCSTN, APP, LRRC7, STAT3, PAFAH1B1, DOCK10, LYN, ARF1, PTK2, ITGA3, CYFIP2, EFNB1, RELA, P2RX4, RTN4, PURA, ADAM10, PTPRZ1, SNAP25, DNM2, FLNA, MAPK1, NEDD4, PTN, FGFR2, PAK2, ANXA1 |
| CC | glutamatergic synapse (GO:0098978) | 14 | BCR, PTK2B, FZD3, STAT3, LYN, ARF1, RELA, PURA, ADAM10, SNAP25, DNM2, FLNA, NEDD4, PAK2 |
| BP | neuron projection development (GO:0031175) | 50 | EPHA2, HSP90AA1, HCLS1, IL6, DAB2IP, PIK3R1, ITGA4, SLC11A2, HES1, ADM, JUN, RAB35, HSP90AB1, SEC24B, PTK2B, FZD3, APP, SHC1, PTPN11, CASP3, LST1, BSG, PAFAH1B1, DOK2, DOCK10, ALCAM, LYN, RPS6KA5, PTK2, EIF2AK4, SRF, CYFIP2, SEMA4A, EFNB1, CSF1R, RTN4, KIF5B, PTPRZ1, NCAM1, HMGB1, DNM2, GATA3, MAPK1, CXCL12, NEDD4, PTN, ITGA1, STK4, FGFR2, PAK2 |
| BP | microglial cell activation (GO:0001774) | 14 | TREM2, C1QA, IFNGR1, JUN, IFNG, CX3CL1, TLR2, APP, TYROBP, TNF, FPR2, AIF1, GRN, C5AR1 |
| BP | astrocyte activation (GO:0048143) | 11 | TREM2, C1QA, IFNGR1, IFNG, PSEN1, APP, TNF, FPR2, IL1B, GRN, C5AR1 |
| BP | regulation of glial cell migration (GO:1903975) | 8 | TREM2, CX3CL1, CCR2, GPR183, CSF1, P2RY12, P2RX4, CCL3 |
| BP | regulation of synapse structure or activity (GO:0050803) | 17 | HCLS1, DAB2IP, DHX36, FCGR2B, TLR2, FZD3, APP, SEMA4D, TNF, PAFAH1B1, SLC7A11, PTK2, SEMA4A, ADAM10, DNM2, NEDD4, PTN |
| BP | synapse pruning (GO:0098883) | 3 | TREM2, C1QA, CX3CL1 |