Figure 1.

Cyclin-dependent kinase 12 (CDK12) overexpression and its correlation with a poor prognosis in cervical cancer (CC). (a) Analysis of CDK12 genetic alterations across various human cancers using TCGA databases. (b) Kaplan-Meier analysis (log-rank test) of the overall survival of patients with CC based on CDK12 genetic alteration, using TCGA databases. (c) Expression profiles of CDK12 in tumors (T) and normal (N) cervical tissue samples GSE6791, which are from Gene Expression Omnibus datasets. (d) Expression profiles of CDK12 in precancerous lesions of the uterine cervix, NC and CC samples from GSE7803. NC: normal cervix; HSIL: high-grade squamous intraepithelial lesion. (e) Representative immunohistochemical images and quantification analysis showing CDK12 expression in human cervical cancer and normal uterine cervix tissue specimens from Sixth hospital (sixth cohort). Scale bar: 200 μm. Two-tailed t-test, ^∗P < 0.05.