Figure 4.

Knockdown of CDK12 suppresses tumor proliferation in vivo. (a), (b) HeLa and Siha cells were infected with shCDK12-1 and shNC and were injected into BALB/C nude mice. Excised tumor in different groups was shown. Four weeks later, tumor volumes and weights in shCDK12-1 were inhibited in comparison with shNC. (c) Typical IHC images of Ki67, and PCNA from xenografts under HeLa and Siha cells treatment with sh-NC and shCDK12-1. Two-tailed t-test, ^∗P < 0.05. Scale bar: 50 μm.