Table 1.
LM revascularization decision making based on FFR or iFR: observational outcome studies.
| Cut-off | Total number of patients | Total number of deferred patients (physiologically nonsignificant) | Total number of revascularized patients (physiologically significant) | Mean follow-up (months) | Odds ratio for MACE of deferred vs. revascularized [36] | |
|---|---|---|---|---|---|---|
| FFR in LM | ||||||
| Bech et al. 2001 [37] | 0.75 | 54 | 24 | 30 | 29 ± 15 | 1.316 (P=0.696) |
| Jiménez-Navarro et al. 2004 [38] | 0.75 | 27 | 20 | 7 | 26 ± 12 | 0.625 (P=0.640) |
| Legutko et al. 2005 [39] | 0.75 | 38 | 20 | 18 | 24 ± 12 | 0.889 (P=0.911) |
| Lindstaedt et al. 2006 [40] | 0.75∗ | 51 | 24 | 27 | 29 ± 16 | 0.952 (P=0.940) |
| Courtis et al. 2009 [41] | 0.75∗ | 142 | 82 | 60 | 14 ± 11 | 3.394 (P=0.038) |
| Hamilos et al. 2009 [42] | 0.80 | 213 | 138 | 75 | 36 (6–99) | 1.415 (P=0.374) |
| Total | 525 | 308 | 217 | 1.434(P=0.152) | ||
|
| ||||||
| iFR in LM | ||||||
| Warisawa et al. 2020 [43] | 0.89 | 314 | 163 | 151 | 30 | 1.45 (P=0.26) |
| Total | 314 | 163 | 151 | 1.45(P=0.26) | ||
LM: left main; FFR: fractional flow reserve; iFR: instantaneous wave-free ratio; ∗for FFR between 0.75 and 0.80, additional clinical data were used to proceed with revascularization.