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. 2021 Jan 8;40(7):1255–1268. doi: 10.1038/s41388-020-01595-3

Fig. 7. Graphical abstract.

Fig. 7

The expression of miRNAs in the chrXq27.3 miRNA cluster, which were abundant in primary ovarian clear cell carcinoma (OCCC), decreased in recurrent/metastatic OCCC. Moreover, their expression was also negative in several patient-derived xenograft (PDX) models and cell lines. In ES-2 cells, miR-509-3p and miR-509-3-5p reversed cisplatin resistance by coordinately regulating the expression of YAP1.