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. 2020 Dec 3;80(3):312–320. doi: 10.1136/annrheumdis-2020-218870

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Proportion of patients achieving (A) PASI75, (B) PASI90 and (C) PASI100. response over 24 weeks. *p≤0.05; for upadacitinib 15 mg QD versus placebo; ^#p≤0.05; for upadacitinib 30 mg QD versus placebo; †significant in the multiplicity-controlled analysis. After week 16, assessments have been performed. Patients may use concomitant treatments specifically for psoriasis per investigator judgement. Results are based on non-responder imputation. 95% CIs for response rate were calculated based on normal approximation to the binominal distribution. 95% CIs for response rate difference were calculated based on normal approximation. Nominal p value was constructed using Cochran-Mantel-Haenszel test adjusted for the main stratification factor of current disease-modifying antirheumatic drug use (yes/no). PASI75/90/100, 75%/90%/100% improvement in Psoriasis Area Severity Index; QD, once per day.