Figure 3.

Expansion of known osteoarthritis (OA) genes. (A) Schematic of network diffusion algorithm used to expand known OA genes. (B) Violin plots demonstrating the ability to recover held-out known OA genes on the basis of network topology. Network diffusion-based ranks of held out known OA genes and unlabelled genes from 100 repeats of fivefold cross validation. (C) Network ranks of the latest reported OA genes from conference abstracts. Expected mean random rank showed by dashed line. (D) Example networks of a highly ranked genes (white), showing interactions to OA genes. The inferred effect of the OA genes and known regulatory interactions are indicated.