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. 2021 Feb 5;11:632239. doi: 10.3389/fimmu.2020.632239

Figure 3.

Figure 3

(A) A new 68 upregulated signature genes are identified in Treg: 11 upregulated genes in our finding, 20 thymic Treg cluster markers were identified based on single cell-sequence by S A Teichmann (PMID: 32079746) and 50 Foxp3-induced Treg signature genes (PMID: 28892470). Venn diagram showed that FOXP3, TNFRSF4, CTLA4, TNFRSF18 were common signature genes which could be upregulated in Treg; IGFBP4 was shared by downregulated gene set we generated and 36 Foxp3-suppressed Treg signature genes. (B) Venn Diagram showed shared consistent upregulated signature genes in four tissues we investigated in our study. (C) Twenty-two out of 27 pathways, shared by upregulated genes of Treg in LN, int and VAT are innate immune pathways as signature pathways of Treg. 15 pathways shared by int and VAT could be identified as peripheral Treg; two pathways shared by LN and int and 12 pathways shared by LN and VAT were classified as transition pathways from lymphoid tissues to non-lymphoid tissues. See the detailed data in Supplementary Figures 2 and 3 .