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. 2021 Feb 5;11:632239. doi: 10.3389/fimmu.2020.632239

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Copyright © 2021 Zhang, Xu, Shao, Sun, Saredy, Cutler, Yao, Liu, Liu, Drummer IV, Lu, Saaoud, Ni, Wang, Li, Li, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Five spleen Treg specific secretomic genes, eight lymph nodes Treg specific secretomic genes, 10 intestine Treg-specific secretomic genes, and 26 VAT Treg-specific secretomic genes are identified, which mediate 20 immune signaling pathways after screening for total 1,706 secretome shared (logFC) in four tissues we studied indicated that secretomic changes of Treg in different tissues could mediate the regulation of leukocyte activation, cytokine production and regulation of immune effector process by upregulated secretomic genes in Treg from four tissues we studied. See the detailed data in Supplementary Figure 6 .