. 2021 Feb 5;11:632239. doi: 10.3389/fimmu.2020.632239

Table 4.

Based on all gene sets analyzed above, we generated a list of Treg signature genes including 68 upregulated and 40 downregulated genes in Figure 4 .

Category	Gene symbol
Upregulated signature ( 66)	FOXP3,FAM129A,TNFRSF4, TNFRSF1B,DUSP4,VAV2,CAPG,CTLA4,TNFRSF18,KLRG1,ITGAE,NRN1,NRP1,GPR83, NEB,IL2RA,GBP3,CSF1,GNAQ,SDC4,IL1RL1,CCR4,ICOS,IL10RA,NT5E,PGLYRP1,LAG3,PRDM1,TGFBR1,MAF,NR4A1, CD200R1,LRRC32,SOCS2,IKZF4,IL2RB,BC005685,IL6RA,CD80,ZSCAN29,TGM2,P2RY10,IGF1R,JUN,LTA,CD69,FOS,PCYT1A, ARHGAP31,TNF,RORC,GBP2,FOLR4,IFGGA2,IL32,PIM2,S100A4,BATF,CARD16,TIGIT,PMAIP1,MIR4435-2HG,CD7,LINC00152,AC133644.2,RTKN2,EPSTI1,IKZF2
Downregulated signature ( 39)	HS3ST3B1,IGFBP4,TMIE,TGFBR3,ATP1B1,VIPR1,FGL2,PDE3B,CXCR6,GZMB,METTL9,LGALS3,PDCD1,TBX21,ID2,IL2,CCR8, IL12RB2,XCL1,FOSL2,LGALS1,EGR1,IL4,POLE,CTLA2A,SLCO4A1,CCR1,LDHA,SLC16A3,CXCR4,IL5,ANLN,CD226,GEN1,EZH2,GZMA,EOMES,IL18RAP,PTPN22,TXN1

Category

Gene symbol

Upregulated signature
( 66)

FOXP3,FAM129A,TNFRSF4, TNFRSF1B,DUSP4,VAV2,CAPG,CTLA4,TNFRSF18,KLRG1,ITGAE,NRN1,NRP1,GPR83,
NEB,IL2RA,GBP3,CSF1,GNAQ,SDC4,IL1RL1,CCR4,ICOS,IL10RA,NT5E,PGLYRP1,LAG3,PRDM1,TGFBR1,MAF,NR4A1,
CD200R1,LRRC32,SOCS2,IKZF4,IL2RB,BC005685,IL6RA,CD80,ZSCAN29,TGM2,P2RY10,IGF1R,JUN,LTA,CD69,FOS,PCYT1A,
ARHGAP31,TNF,RORC,GBP2,FOLR4,IFGGA2,IL32,PIM2,S100A4,BATF,CARD16,TIGIT,PMAIP1,MIR4435-2HG,CD7,LINC00152,AC133644.2,RTKN2,EPSTI1,IKZF2

Downregulated signature
( 39)

HS3ST3B1,IGFBP4,TMIE,TGFBR3,ATP1B1,VIPR1,FGL2,PDE3B,CXCR6,GZMB,METTL9,LGALS3,PDCD1,TBX21,ID2,IL2,CCR8,
IL12RB2,XCL1,FOSL2,LGALS1,EGR1,IL4,POLE,CTLA2A,SLCO4A1,CCR1,LDHA,SLC16A3,CXCR4,IL5,ANLN,CD226,GEN1,EZH2,GZMA,EOMES,IL18RAP,PTPN22,TXN1