Table 7A.
The expression changes of 305 signature genes of 13 cell death pathways were identified to reveal the main pattern of cell death in Treg from different tissues.
| Category | Apoptosis | ADCD regulated | Anoikis related | Entotic cell death | Ferroptosis | ICD regulated | Lysosome dependent cell death | Mitotic cata-strophe regulated | MPT-driven necrosis | Necro-ptosis | NETotic | Par Thanatos | Pyroptosis | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Associated gene | 102 | 22 | 10 | 23 | 24 | 23 | 7 | 28 | 18 | 10 | 12 | 3 | 23 | 305 | |
| SP | Total | 0 | |||||||||||||
| LN | Up | 2 | 1 | 0 | 0 | 0 | 2 | 0 | 3 | 0 | 1 | 0 | 0 | 5 | 14 |
| Down | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |
| Total | 2 | 1 | 0 | 1 | 0 | 2 | 0 | 3 | 0 | 1 | 0 | 0 | 5 | 15 | |
| Int | Up | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 10 |
| Down | 2 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | |
| Total | 3 | 1 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 5 | 17 | |
| VAT | Up | 5 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 2 | 1 | 0 | 2 | 16 |
| Down | 3 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | |
| Total | 8 | 0 | 0 | 3 | 3 | 1 | 0 | 2 | 0 | 2 | 1 | 0 | 3 | 23 | |
We found that with the tiers of tissue changes, the number of changed genes were increased, indicating modification of cell death pathways may be one of the mechanisms in Treg development of different tissues.