Figure 3.

CCL1 but not CCL8 protects from DSS colitis. C57BL/6 (A-C) or Ccr8 ^−/− (D-F) mice were intravenously treated with 5 μg of expression vectors (CCL1, CCL8, and Mock). Two days later, the mice were treated with 2% of DSS in drinking water for 7 days. (A, D) Schematic overview of the procedure. (B, E) Relative body weight. (C, F) Representative H&E stainings of colonic cross sections and histological scoring of mucosal damage. Scale bar 500 µm and 200 µm. All graphs show data of one representative experiment out of three to four independent experiments with four to six mice per group. Statistical analyses were performed using one-way ANOVA. Data is shown as mean ± S.E.M.: *P ≤ 0.05; **P ≤ 0.01; ****P ≤ 0.0001, ns, not significant.