Figure 2.

Palisades and pseudopalisading cells. Palisades are defined as a protective layer, similar to a fence or perimeter of wooden stakes or iron railings. (top figure) In glioblastoma, pseudopalisades or “false palisades” are dense migratory zones of cells in picket-fence or perimeter formation, which surround necrotic tissue; hence the term, “pseudopalisading necrosis”. The pervasive hypothesis is that pseudopalisading cells are “microenvironmental migrants” that co-localize in search of better oxygenated conditions due to the presence of vascular collapse and necrosis (40). (bottom figure)