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Key aspects of BAFF-R, TACI, and BCMA signaling within the context of CVID. BAFF-R is distinguished by its ability to signal via the non-canonical NF-kB pathway to induce Bcl-2 and other pro-survival factors. Lack of memory B cells and plasma cells expressing TACI and BCMA in CVID may increase signaling via BAFF-R. CSR, class-switch recombination; TI, T-independent.
