Table 1.
Important characteristics of the receptors for BAFF.
| BAFF-R (TNFRSF13C) | TACI (TNFRSF13B) | BCMA (TNFRSF17) | |
|---|---|---|---|
| B cell subset expression | Naïve & transitional B cells | Marginal zone & class-switched memory B cells | Plasma cells |
| Ligands | BAFF trimer, BAFF 60mer | BAFF 60mer, APRIL, HSPGs | BAFF, APRIL |
| TRAF Interactions | TRAF3 TRAF6 TRAF2 (thru TRAF3) |
TRAF2 TRAF3 TRAF5 TRAF6 |
TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 |
| Signaling pathways | Non-canonical NF-κB Canonical NF-κB PI3K-Akt |
Canonical NF-κB NFAT MyD88-dependent CSR |
Canonical NF-κB |
| Effects upon B cells | Pro-survival Enhanced proliferation Resistance to apoptosis |
Cell cycle arrest Apoptosis TI class switching to IgG, IgA Plasma cell differentiation |
Survival of plasma cells |
| Extracellular CRDs | 1 (shorter) | 2 | 1 |
| Soluble receptor processing | ADAM10, ADAM17 (BAFF & TACI-dependent) |
ADAM10, γ-secretase, ADAM17 | γ-secretase |