Table 3.
Univariate and multiple regression analysis using V̇O2peak % of predicted as dependent variable in long-term survivors of allo-HSCT (n = 90)
| Variable | Unadjusted (ß) | 95% CI | p value | Adjusted (ß)1 | 95% CI | p value |
|---|---|---|---|---|---|---|
| Female gender | 5 | (− 2.6, 12.6) | 0.2 | |||
| BMI | − 1.1 | (− 1.8, − 0.4) | 0.002 | − 1.4 | (− 2.0, − 0.8) | < 0.001 |
| Age at allo-HSCT | 0.2 | (− 0.2, 0.6) | 0.26 | |||
| Chronic GVHD w/o BOS | − 2.5 | (− 10.8, 5.8) | 0.55 | |||
| BOS | − 14.6 | (− 25.8, − 3.4) | 0.01 | − 15.2 | (− 24.9, − 5.4) | 0.003 |
| Physical activity | 8.8 | (0.6, 17.0) | 0.04 | 7.3 | (0.2, 14.4) | 0.04 |
| DLCO % of predicted | 0.2 | (− 0.01, 0.5) | 0.06 | 0.2 | (0.04, 0.5) | 0.02 |
| LVEF | 0.6 | (− 0.03, 1.3) | 0.06 | 0.6 | (0.07, 1.2) | 0.03 |
1Adjusted for all shown variables. Allo-HSCT, Allogeneic hematopoietic stem cell transplantation; BOS, bronchiolitis obliterans syndrome; BMI, body mass index; GVHD, graft-versus-host disease; DLCO, diffusing capacity for carbon monoxide; physical activity according to the World Health Organization recommendation; LVEF, left ventricular ejection fraction