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. 2021 Feb 18;12(2):191. doi: 10.1038/s41419-021-03466-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Three potential targets (PCBP2, RTKN, and RAD23B) for miR-145-5p were revealed. B Relative RTKN expression was determined in IR-treated HK-2 cells. C The influence of miR-145-5p mimics and miR-145-5p inhibitor on RTKN expression was determined by RT-qPCR. D RIP assay demonstrated relative enrichment of miR-145-5p and RTKN in the anti-IgG and anti-Ago2 groups. E The binding site of RTKN and miR-145-5p was predicted from starBase. F, G Luciferase activity revealed the influence of miR-145-5p mimics and miR-145-5p inhibitor on luciferase activity of pmirGLO RTKN-Wt and pmirGLO RTKN-Mut plasmids. H RTKN expression was determined by RT-qPCR in HK-2 cells transfected with sh-NC, sh-MEG3, and sh-MEG3 + miR-145-5p inhibitor. *p < 0.05, **p < 0.01.