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. 2021 Feb 18;11:4219. doi: 10.1038/s41598-021-83685-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor stiffness is associated with high myofibroblast content in Mesenchymal HGSOC. (A) Representative views of HES staining showing stromal (orange) and epithelial (pink) compartments in soft and stiff Mesenchymal and Non-Mesenchymal tumors. Scale bar, 200 μm. (B) Same as in (A) showing smooth muscle α-actin (SMA) immunostaining. (C) Scatter plot showing percentages of stroma in soft (dot) versus stiff (triangle) Mesenchymal (OV26: soft n = 9, stiff n = 11; OV21: soft n = 13, stiff n = 9) and Non-Mesenchymal (n = 15) HGSOC. Data are shown as mean ± S.E.M. P values from Mann Whitney test. (D) Same as in (C) showing SMA histological scores (Hscores). P values from Welch's t-test. (E–G) Same as in (A) at the center (top) and periphery (bottom) of soft (left) and stiff (right) Mesenchymal (E,F) and Non-Mesenchymal (G) HGSOC. (H–J) Scatter plot showing percentages of stroma at the center (C, plain) and periphery (P, empty) in soft (dot) versus stiff (triangle) Mesenchymal (OV26: soft n = 6, stiff n = 6) (H); (OV21: soft n = 13, stiff n = 9) (I) and Non-Mesenchymal (n = 15) (J) HGSOC. Data are shown as mean ± S.E.M. P values from Welch's t-test.